Halofuginone may suppresses azoxymethane-induced serum tumor necrosis factor-a synthesis and aberrant crypt foci progression in rat colon

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dc.contributor.authorCorum, Orhan
dc.contributor.authorOzdemir, Ozgur
dc.contributor.authorYazar, Enver
dc.date.accessioned2020-03-26T19:41:49Z
dc.date.available2020-03-26T19:41:49Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this research was to investigate the effect of halofuginone on the progression of azoxymethane-induced colon cancer in rats. A total of 38 male Wistar albino rats were divided into 4 groups: Control (n=8), Halofuginone (n= 10, 0.4 mg/kg, PO, SID), Cancer (n=10, azoxymethane, 15 mg/kg, IP, once a week for two weeks) and Cancer + Halofuginone (n=10). After 18 weeks, blood samples were taken under anesthesia and all animals were sacrificed. Aberrant crypt foci in the colon were stained with methylene blue. Blood cytokines, thiobarbituric acid reactive substances, 13,14-dihydro-15-ketoprostaglandin F2 alpha levels, hemogram and biochemical values were measured. The tumor necrosis factor-a level in the Cancer group was higher (P<0.05) than in other groups, while higher numbers of aberrant crypt foci were found in the Cancer group compared with the Cancer + Halofuginone group (P<0.05). In summary, it may be stated that halofuginone may warrant evaluation as a supportive drug in the treatment of colon cancer in the future.en_US
dc.description.sponsorshipOYPMinistry of National Education - Turkey [2013-OYP-52]en_US
dc.description.sponsorshipThis research was summarized from the PhD thesis of the first author. A portion of the abstract was presented as a poster at the 9th European Colorectal Congress (ECC) 2015, 1st to 4th December 2015, St. Gallen, Switzerland. Research was supported by OYP (2013-OYP-52).en_US
dc.identifier.doi10.18805/ijar.v0i0f.7600en_US
dc.identifier.endpage1124en_US
dc.identifier.issn0367-6722en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1120en_US
dc.identifier.urihttps://dx.doi.org/10.18805/ijar.v0i0f.7600
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35161
dc.identifier.volume51en_US
dc.identifier.wosWOS:000422711500025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAGRICULTURAL RESEARCH COMMUNICATION CENTREen_US
dc.relation.ispartofINDIAN JOURNAL OF ANIMAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAberrant crypt focien_US
dc.subjectColon canceren_US
dc.subjectCytokinesen_US
dc.subjectHalofuginoneen_US
dc.titleHalofuginone may suppresses azoxymethane-induced serum tumor necrosis factor-a synthesis and aberrant crypt foci progression in rat colonen_US
dc.typeArticleen_US

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