Effect of Erythropoietin on Microvascular Anastomosis in Rat

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dc.contributor.authorSenturk, Sadik
dc.contributor.authorKaracor, Zeynep
dc.contributor.authorTosun, Zekeriya
dc.contributor.authorOzkan, Adem
dc.contributor.authorAvunduk, M. Cihat
dc.contributor.authorZumrut, Murat
dc.date.accessioned2020-03-26T19:02:05Z
dc.date.available2020-03-26T19:02:05Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To investigate the re-endothelialization potential of erythropoietin (EPO) following microvascular anastomosis in rat femoral artery. Methods: Ninety-six male Sprague-Dawley rats weighing between 300 g and 320 g were allocated randomly into two groups (control and EPO, n = 48). Left femoral artery microvascular anastomosis was performed in the rats. The control group was given 0.5 mL of 0.09 % NaCl subcutaneously 48 h post-operatively while the EPO group was given 150 U/kg recombinant human erythropoietin subcutaneously 48 h post-operatively. Tissue was harvested from each group after 1, 3, 5, and 7 days. All of the rats were sacrificed for morphometric analysis. Each arterial segment was analyzed morphometrically using Clemex Image Analysis software by a single examiner. The cross-sectional area of the media and neointima was measured and the intima/media ratio was calculated. Hematocrit measurement was carried out for all the rats. Results: The I/M ratio differed significantly (p < 0.05) between the control and erythropoietin groups, at all time-points. The hematocrit was significantly (p < 0.05) lower in the control group than in the erythropoietin groups on day 7, but not on the other days. Conclusion: This study demonstrates that erythropoietin markedly inhibits neointima formation with accelerated re-endothelialization in rat femoral arteries following microvascular anastomosis.en_US
dc.identifier.doi10.4314/tjpr.v14i9.12en_US
dc.identifier.endpage1634en_US
dc.identifier.issn1596-5996en_US
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1629en_US
dc.identifier.urihttps://dx.doi.org/10.4314/tjpr.v14i9.12
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32039
dc.identifier.volume14en_US
dc.identifier.wosWOS:000364708300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPHARMACOTHERAPY GROUPen_US
dc.relation.ispartofTROPICAL JOURNAL OF PHARMACEUTICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectErythropoietinen_US
dc.subjectMicrovascular anastomosisen_US
dc.subjectRe-endothelializationen_US
dc.subjectHematocriten_US
dc.subjectNeointima/media ratioen_US
dc.titleEffect of Erythropoietin on Microvascular Anastomosis in Raten_US
dc.typeArticleen_US

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