677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with Spina bifida occulta [Spina bifida okkultali hastalarda metilentetrahidrofolat redüktaz (MTHFR) geninin C677T ve A1298C polimorfizmlerinin analizi ve biyokimyasal parametrelerinin de?erlendirilmesi]

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dc.contributor.authorEser B.
dc.contributor.authorCosar M.
dc.contributor.authorEser O.
dc.contributor.authorErdogan M.O.
dc.contributor.authorAslan A.
dc.contributor.authorYildiz H.
dc.contributor.authorBoyaci G.
dc.date.accessioned2020-03-26T18:05:35Z
dc.date.available2020-03-26T18:05:35Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. Material and Methods: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. Results: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x2=3.325, P=0.068; x2=1.479, P=0.224; x2=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x2=8.477, P=0.004). The frequencies of the Aand C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x2=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). Conclusion: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.en_US
dc.identifier.endpage15en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue1en_US
dc.identifier.pmid20066615en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25473
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject1298A>C polymorphismen_US
dc.subject677C>T polymorphismen_US
dc.subjectFolateen_US
dc.subjectHomocysteineen_US
dc.subjectMTHFRen_US
dc.subjectSpina bifida occultaen_US
dc.subjectVitamin B12en_US
dc.title677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with Spina bifida occulta [Spina bifida okkultali hastalarda metilentetrahidrofolat redüktaz (MTHFR) geninin C677T ve A1298C polimorfizmlerinin analizi ve biyokimyasal parametrelerinin de?erlendirilmesi]en_US
dc.typeArticleen_US

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