Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case control study

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dc.contributor.authorÇintesun, Ersin
dc.contributor.authorAkar, Serra
dc.contributor.authorGül, Ayhan
dc.contributor.authorÇintesun, Feyza Nur İncesu
dc.contributor.authorŞahin, Gözde
dc.contributor.authorEzveci, Huriye
dc.contributor.authorAkyürek, Fikret
dc.contributor.authorÇelik, Çetin
dc.date.accessioned2020-03-26T20:19:19Z
dc.date.available2020-03-26T20:19:19Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractINTRODUCTION: Subclinical inflammation markers play a significant role in hyperemesis gravidarum (HEG). Simple hematological markers such as mean platelet volume (MPV), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW), plateletcrit (PCT), and platelet-to-lymphocyte ratio (PLR) have been shown to reflect inflammatory burden and disease activity in several disorders. Ketonuria is a parameter used in the diagnosis of severe HEG, but its correlation with disease severity remains controversial. The relationship of subclinical inflammation markers with degree of ketonuria has not been examined previously. In this study, we aimed to determine the diagnostic value of these subclinical inflammation markers and the relationship between these markers and grade of ketonuria in patients with HEG. MATERIALS AND METHODS: A total of 94 pregnant women with a diagnosis of HEG and 100 gestational age-matched healthy pregnant women were enrolled in this retrospective study. MPV, PDW, NLR, PLR, PCT, and ketonuria were calculated and analyzed from complete blood cell counts and total urine analyses. RESULTS: Lymphocyte count was significantly higher in the control group (P< 0,001): NLR and PLR values were significantly higher in the HEG group (P< 0,001). Among inflammation markers, RDW increased significantly (P = 0,008) with an increase in ketonuria in patients with HEG. A statistically significant correlation was found between white blood cell (WBC) and NLR, PLR, PCT. A moderate uphill relationship was observed between NLR and WBC and a weak uphill linear relationship was observed between WBC and PLR and between WBC and PCT CONCLUSIONS: PLR and NLR can be considered effective markers to aid in the diagnosis of HEG. No marker was found to correlate with ketonuria grade except RDW, although the relationship of the severity of ketonuria with severity of disease is controversial. RDW increases as the degree of ketonuria increases.en_US
dc.identifier.citationÇintesun, E., Akar, S., Gul, A., Çintesun, F. N. I., Sahin, G., Ezveci, H., Akyurek, F., Çelik, Ç. (2019). Subclinical İnflammation Markers İn Hyperemesis Gravidarum And Ketonuria: A Case Control Study. Journal Of Laboratory Physıcıans, 11,(2), 149-153.
dc.identifier.doi10.4103/JLP.JLP_151_18en_US
dc.identifier.endpage153en_US
dc.identifier.issn0974-2727en_US
dc.identifier.issn0974-7826en_US
dc.identifier.issue2en_US
dc.identifier.pmid31160855en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://dx.doi.org/10.4103/JLP.JLP_151_18
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38212
dc.identifier.volume11en_US
dc.identifier.wosWOS:000470265000010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇintesun, Ersin
dc.institutionauthorAkar, Serra
dc.institutionauthorGul, Ayhan
dc.institutionauthorSahin, Gozde
dc.institutionauthorEzveci, Huriye
dc.institutionauthorÇelik, Çetin
dc.language.isoenen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSen_US
dc.relation.ispartofJOURNAL OF LABORATORY PHYSICIANSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHyperemesis gravidarumen_US
dc.subjectketonuriaen_US
dc.subjectsubclinical inflammationen_US
dc.titleSubclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case control studyen_US
dc.typeArticleen_US

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