Multiple biological activities of two Onosma species (O. sericea and O. stenoloba) and HPLC-MS/MS characterization of their phytochemical composition

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dc.contributor.authorStankovic, Jelena S. Katanic
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMatic, Sanja
dc.contributor.authorJuric, Tatjana
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T20:20:23Z
dc.date.available2020-03-26T20:20:23Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractMembers of the Onosma genus are widely used in folk medicine and they have great interest in the pharmaceutical industry. In this study, phytochemical characterization, antioxidant activity (2,2-dipheny1-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CIJPRAC), metal chelation, and phosphomolybdenum assays), enzyme inhibition (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-amylase, alpha-glucosidase, and tyrosinase), antimicrobial activity (microdilution method), genotoxic and antigenotoxic (by using Drosophila melanogaster larvae and Comet assay) potentials of Onosma sericea Willd. and Onosma stenoloba Hausskn. ex Riedl. were investigated. Additionally, the bioactive compounds were identified by high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) analysis. Generally, O. sericea showed stronger antioxidant activity, while O. stenoloba extract exhibited stronger enzyme inhibitory abilities (cholinesterases and alpha-amylase). The protective effects of extracts, at the concentration range from 25 to 400 mu g/mL, against hydroxyl radical-induced DNA damage were dose-dependent, increasing with a higher dosage. The extracts at the highest concentration (80 mg/mL) showed the absence of genotoxicity in vivo. Antigenotoxic effects were evident after treatment with both extracts, with a percentage reduction of over 80 %. Overall antimicrobial activity of studied extracts was weak, with the lowest minimal inhibitory concentration values (MIC) of 2.5 mg/mL. Taken together, obtained results showed that tested Onosma species can be considered as promising sources of bioactive phytochemicals for pharmacological purposes.en_US
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia [III43004]en_US
dc.description.sponsorshipThis study was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant No.III43004).en_US
dc.identifier.citationStankovic, J. S. K., Ceylan, R., Zengin, G., Matic, S., Juric, T., Diuzheva, A., Jeko, J., Cziaky, Z., Aktümsek, A. (2020). Multiple Biological Activities of Two Onosma Species (O. sericea and O. stenoloba) and HPLC-MS/MS Characterization of Their Phytochemical Composition. Industrial Crops & Products, 144, 1-10.
dc.identifier.doi10.1016/j.indcrop.2019.112053en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.112053
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38573
dc.identifier.volume144en_US
dc.identifier.wosWOS:000510521700022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorCeylan, Ramazan
dc.institutionauthorZengin, Gökhan
dc.institutionauthorAktümsek, Abdurrahman
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOnosmaen_US
dc.subjectAntigenotoxicen_US
dc.subjectNatural agentsen_US
dc.subjectFlavonoidsen_US
dc.subjectEnzyme inhibitionen_US
dc.titleMultiple biological activities of two Onosma species (O. sericea and O. stenoloba) and HPLC-MS/MS characterization of their phytochemical compositionen_US
dc.typeArticleen_US

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