Elucidation of biological properties of some commercial anthraquinones: Mutagenic / antimutagenic and antimicrobial activity approaches

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dc.authorid0000-0002-9297-4050
dc.authorid0000-0003-2833-5710
dc.authorid0000-0002-0511-9575
dc.contributor.authorUysal, Ahmet.
dc.contributor.authorGüneş, Erdoğan.
dc.contributor.authorDurak, Yusuf.
dc.date.accessioned2020-03-26T20:13:54Z
dc.date.available2020-03-26T20:13:54Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractAnthraquinones (AQ) are the most common group of naturally occurring quinones. Both natural and synthetic AQs have been used as colorants in food, drugs and cosmetic industries. The aim of this study was to evaluate the mutagenic/antimutagenic potentials of some AQs (Alizarin, quinizarin, purpurin, and 1,8-dihydroxy anthraquinone) with Salmonella typhimurium TA98 and TA100 strains by Ames test and antimicrobial activity by broth microdilution method. So, AQs were tested for their toxicity and nontoxic doses of the chemicals were used. The results manifested that none of the chemicals were mutagenic for TA98 and TA100 strains both with and without metabolic activation enzymes (S9 mix). Purpurin and alizarin exhibited strong antimutagenic effects against 4-nitrophenylendiameine and 2-aminoflourene at all test doses (1000, 500 and 250 mu g/plate) for TA98; and against sodium azide and 2-aminoanthracene for TA100. Alizarin showed the highest inhibition rate (93%) against sodium azide at a concentration of 1000 mu g/plate. While 1,8-dihydroxy anthraquinone and quinizarin revealed strong antimutagenicity at 10000 mu g/plate without S9 mix, they exhibited excellent antimutagenic action after addition of S9 enzymes for TA98 strain at all test doses. Similarly, 1,8-dihydroxy anthraquinone and quinizarin were moderate antimutagenic against sodium azide at all test doses without S9 mix, their antimutagenicity increased and they ameliorated the mutagenic action of 2-aminoanthracene by the addition of S9 for TA100. These two chemicals were strong antimutagenic against promutagens activated by S9 mix. Also it was defined that purpurin and alizarin have antimicrobial capacity against MRSA strains.en_US
dc.identifier.citationUysal, A., Güneş, E., Durak, Y. (2019). Elucidation of Biological Properties of Some Commercial Anthraquinones: Mutagenic/Antimutagenic and Antimicrobial Activity Approaches. Journal of Research in Pharmacy, 23(2), 208-216.
dc.identifier.doi10.12991/jrp.2019.126en_US
dc.identifier.endpage216en_US
dc.identifier.issn2630-6344en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://dx.doi.org/10.12991/jrp.2019.126
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37783
dc.identifier.volume23en_US
dc.identifier.wosWOS:000459615300007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorUysal, Ahmet.
dc.institutionauthorGüneş, Erdoğan.
dc.institutionauthorDurak, Yusuf.
dc.language.isoenen_US
dc.publisherMARMARA UNIVen_US
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlizarinen_US
dc.subjectquinizarinen_US
dc.subjectpurpurinen_US
dc.subject1,8-dihydroxy anthraquinoneen_US
dc.subjectAmes testen_US
dc.subjectantimicrobialen_US
dc.titleElucidation of biological properties of some commercial anthraquinones: Mutagenic / antimutagenic and antimicrobial activity approachesen_US
dc.typeArticleen_US

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