Dynamic thiol/disulfide homeostasis in predicting adverse neonatal outcomes in fetal growth restriction

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dc.authorid0000-0002-2996-3236
dc.contributor.authorOzler, Sibel.
dc.contributor.authorOztas, Efser.
dc.contributor.authorGuler, Basak Gumus.
dc.contributor.authorErel, Ozcan.
dc.contributor.authorCaglar, Ali Turhan.
dc.contributor.authorErgin, Merve.
dc.contributor.authorDanisman, Nuri.
dc.date.accessioned2020-03-26T20:13:32Z
dc.date.available2020-03-26T20:13:32Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: The main aim of this study was to investigate thiol/disulfide homeostasis associated with fetal growth restriction (FGR) and to evaluate whether alterations are predictive for adverse neonatal outcomes. Methods: 273 pregnant women (77 with FGR and 196 with normal fetal growth) were enrolled in this prospective case-control study. Results: Native thiol and total thiol were decreased in FGR compared to the control group (p < .001; p < .001). Decreased levels of maternal serum native and total thiol were significantly associated with adverse neonatal outcomes in FGR (OR: 0.983, 95% CI 0.976-0.991, p < .001; OR: 0.983, 95% CI 0.976-0.991, p < .001). Decreased maternal serum total thiol levels were the only significantly associated risk factor with adverse neonatal outcomes in FGR (OR: 0.981, 95% CI 0.963-1.000, p = .046). Conclusion: The decrease in the antioxidants of thiol/disulfide mechanism may be related to the development of both FGR and adverse neonatal outcome in FGR.en_US
dc.identifier.citationOzler, S., Oztas, E., Guler, B. G., Erel, O., Caglar, A. T., Ergin, M., Danisman, N. (2019). Dynamic Thiol/Disulfide Homeostasis in Predicting Adverse Neonatal Outcomes in Fetal Growth Restriction. Fetal and Pediatric Pathology, 39(2), 132-144.
dc.identifier.doi10.1080/15513815.2019.1644686en_US
dc.identifier.issn1551-3815en_US
dc.identifier.issn1551-3823en_US
dc.identifier.pmid31362586en_US
dc.identifier.urihttps://dx.doi.org/10.1080/15513815.2019.1644686
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37712
dc.identifier.wosWOS:000479402300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOzler, Sibel.
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofFETAL AND PEDIATRIC PATHOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFetal growth restrictionen_US
dc.subjectdynamic thiol disulfide homeostasisen_US
dc.subjectadverse neonatal outcomesen_US
dc.titleDynamic thiol/disulfide homeostasis in predicting adverse neonatal outcomes in fetal growth restrictionen_US
dc.typeArticleen_US

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