GC-MS analysis and antimicrobial activity of alkaloid extract from Genista vuralii

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dc.contributor.authorErdemoglu, Nurgun
dc.contributor.authorOzkan, Semiha
dc.contributor.authorDuran, Ahmet
dc.contributor.authorTosun, Fatma
dc.date.accessioned2020-03-26T17:38:45Z
dc.date.available2020-03-26T17:38:45Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, the alkaloid composition of the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae) was investigated by capillary GC-MS. Ten quinolizidine alkaloids were identified by capillary GC-MS, namely, N-methylcytisine, cytisine, tetrahydrorhombifoline, 17-oxosparteine, 5,6-dehydrolupanine, lupanine, 17-oxolupanine, anagyrine, baptifoline, and 13 alpha-tigloyloxylupanine. Among them, anagyrine (93.04%) was the most abundant alkaloid. Furthermore, antibacterial and antifungal activities of the alkaloid extract of G. vuralii were tested against standard strains of bacteria (Escherichia coli, Pseudomonos aeruginosa, Bacillus subtilis, Staphylococcus aureus) as well as fungi (Candida albicans, Candida krusei). The alkaloid extract of G. vuralii presented good activity against S. aureus, B. subtilis, and C krusei, with minimum inhibitory concentrations (MIC) of 62.5 mu g/mL. The remaining MIC values were found to range between 125 and 500 mu g/mL. To the best of our knowledge, the current work is the first to report the alkaloid profile and antimicrobial activity of G. vuralii L. growing in Turkey.en_US
dc.identifier.doi10.1080/13880200802448674en_US
dc.identifier.endpage85en_US
dc.identifier.issn1388-0209en_US
dc.identifier.issn1744-5116en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://dx.doi.org/10.1080/13880200802448674
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23566
dc.identifier.volume47en_US
dc.identifier.wosWOS:000266630700015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofPHARMACEUTICAL BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlkaloidsen_US
dc.subjectantimicrobial activityen_US
dc.subjectFabaceaeen_US
dc.subjectGC-MSen_US
dc.subjectGenistaen_US
dc.subjectGenista vuraliien_US
dc.titleGC-MS analysis and antimicrobial activity of alkaloid extract from Genista vuraliien_US
dc.typeArticleen_US

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