Are cytokine levels in serum, endometrial tissue, and peritoneal fluid a promising predictor to diagnosis of endometriosis-adenomyosis?

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dc.contributor.authorOzcelik, K.
dc.contributor.authorCapar, M.
dc.contributor.authorUcar, M. Gazi
dc.contributor.authorCakur, T.
dc.contributor.authorOzcelik, F.
dc.contributor.authorIlhan, T. Tuyan
dc.date.accessioned2020-03-26T19:23:07Z
dc.date.available2020-03-26T19:23:07Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The basic aim was to find a non-invasive procedure to diagnose and monitor endometriosis-adenomyosis. Materials and Methods: A prospective study was carried out. The authors conducted a series of 60 consecutive patients who underwent diagnostic laparoscopy for benign gynecologic conditions. Endometrial, peripheral blood and peritoneal lavage samples were analyzed. IL-6, IL-16, TNF-alpha, and LIF levels were measured and compared. Results: The authors analyzed clinical data of 52 patients (26 endometriosis, 13 adenomyosis, and 13 control group). Peritoneal fluid IL-6 is significantly higher in stage IV endometriosis group than the control group (p = 0.001). In the endometriosis group, the levels of TNF-alpha in the peritoneal fluid was higher than the control group (p = 0.008). In the endometriosis and adenomyosis groups, the levels of IL-16 in the peritoneal fluid were significantly higher than the control group (p - 0.000 and p - 0.002). Conclusions: Significant immune-inflammatory changes were observed. When the underlying molecular mechanisms will be investigated, this will elicit studies on the immunotherapeutic treatment of endometriosis. Further studies are needed to assess various potential therapeutic interests for biomarkers in a large, well-defined patient population.en_US
dc.identifier.doi10.12891/ceog3022.2016en_US
dc.identifier.endpage572en_US
dc.identifier.issn0390-6663en_US
dc.identifier.issue4en_US
dc.identifier.pmid29734551en_US
dc.identifier.startpage569en_US
dc.identifier.urihttps://dx.doi.org/10.12891/ceog3022.2016
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33276
dc.identifier.volume43en_US
dc.identifier.wosWOS:000385006200023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G CANADA, INCen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytokinesen_US
dc.subjectIL-6en_US
dc.subjectEndometriosisen_US
dc.subjectPeritoneal fluiden_US
dc.subjectTumor necrosis factor-alpha (TNF-alpha)en_US
dc.titleAre cytokine levels in serum, endometrial tissue, and peritoneal fluid a promising predictor to diagnosis of endometriosis-adenomyosis?en_US
dc.typeArticleen_US

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