EFFECTS OF DIFFERENT DOSES OF DEXAMETHASONE PLUS FLUNIXIN MEGLUMINE ON SURVIVAL RATE IN LETHAL ENDOTOXEMIA

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dc.contributor.authorEr, Ayşe
dc.contributor.authorÜney, Kamil
dc.contributor.authorAltan, Feray
dc.contributor.authorÇetin, Gül
dc.contributor.authorYazar, Enver
dc.contributor.authorElmas, Muammer
dc.date.accessioned2020-03-26T17:38:26Z
dc.date.available2020-03-26T17:38:26Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEffects of different doses of dexamethasone plus flunixin meglumine on survival rate were investigated in lethal endotoxemia. A total of 60 Balb/C female mice were divided into 4 equal groups. Lethal endotoxemia (80-100%) was induced by lipopolysaccharide injection (Group 1, 1 mg, intraperinoneally). At 4 hours after the lipopolysaccharide injection; low-dose dexamethasone (0.6 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously), normal-dose dexamethasone (2 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) and high-dose dexamethasone (10 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) were injected to Group 2, 3 and 4, respectively. After the injections, survival was monitored at 7 days and 13.3%, 13.3%, 33.3% and 73.3% survival rates were observed in Groups 1, 2, 3 and 4, respectively. As results, high-dose dexamethasone plus flunixin meglumine may be the treatment of choice for endotoxaemia in animals.en_US
dc.identifier.doi10.2298/AVB0901047Een_US
dc.identifier.endpage51en_US
dc.identifier.issn0567-8315en_US
dc.identifier.issn1820-7448en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://dx.doi.org/10.2298/AVB0901047E
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23480
dc.identifier.volume59en_US
dc.identifier.wosWOS:000264662100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDE GRUYTER POLAND SP ZOOen_US
dc.relation.ispartofACTA VETERINARIA-BEOGRADen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectlethal endotoxaemiaen_US
dc.subjectdexamethasoneen_US
dc.subjectflunixinen_US
dc.subjectsurvival rateen_US
dc.titleEFFECTS OF DIFFERENT DOSES OF DEXAMETHASONE PLUS FLUNIXIN MEGLUMINE ON SURVIVAL RATE IN LETHAL ENDOTOXEMIAen_US
dc.typeArticleen_US

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