Effcacy of experimental inactivated and live Rhodococcus equi vaccines for thoroughbred Arabian mares in mice

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dc.contributor.authorErganiş, Osman
dc.contributor.authorHadimli, Hasan Hüseyin
dc.contributor.authorSayın, Zafer
dc.contributor.authorSakmanoğlu, Aslı
dc.contributor.authorPınarkara, Yasemin
dc.contributor.authorÖzdemir, Özgür
dc.date.accessioned2020-03-26T19:00:06Z
dc.date.available2020-03-26T19:00:06Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effcacy of inactive Rhodococcus equi vaccine candidates included that bacterinaluminum hydroxide (Al(OH)3), bacterinVapA(Al(OH)3), bacterinMontanide IMS 3012 (IMS), bacterinVapAIMS, and live vaccine using mice as a model. Te efcacy of vaccine was evaluated according to clinical fndings, humoral and cellular immunity (levels of INF-g and IL-4), and results of microbiological culture from internal organs in dead or sacrifced mice. Inactive R. equi vaccines were subcutaneously administered to mice three times at 15-day intervals and live vaccine was intraperitoneally injected once. Fifeen days afer the last vaccination, aerosol challenges were carried out with the pathogenic R. equi VapAK2002 strain in all groups. Two mice were sacrifced from each challenge groups on days 1, 3, 5, and 7. The antibody titers of vaccinated mice were found to be signifcantly higher than those of the controls. The largest number of INF-g positive samples were detected in the bacterinVapAIMS and bacterinIMS groups. IL-4 positivity was determined only in live vaccine groups. The lowest reisolation rate of R. equi from internal organs was observed in the bacterinVapAIMS group. It was concluded that R. equi vaccines, and especially bacterinVapAIMS, are useful to protect mice against R. equi infection.en_US
dc.identifier.endpage301en_US
dc.identifier.issn1300-0128en_US
dc.identifier.issn1303-6181en_US
dc.identifier.issue3en_US
dc.identifier.startpage295en_US
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TVRjeE9EZzVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31697
dc.identifier.volume39en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Veterinary and Animal Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectZiraat Mühendisliğien_US
dc.titleEffcacy of experimental inactivated and live Rhodococcus equi vaccines for thoroughbred Arabian mares in miceen_US
dc.typeArticleen_US

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