İkiuçlu bozuklukta metabolik sendrom, serum leptin düzeyleri ve tedavi ilişkisi
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Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada ikiuçlu bozuklukta metabolik sendrom, serum leptin seviyeleri ve tedavi arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Yöntem: En az 3 ay süre ile atipik antipsikotik (AA) (risperidon, ketiapin, olanzapin) almış 31 ve duygudurum düzenleyici (DD) (lityum, valproik asit, karbamazepin, lamotrijin) almış 29 hasta olmak üzere ikiuçlu bozukluk I tanısı konan ötimik dönemdeki toplam 60 hasta çalışmaya alındı. Metabolik Sendrom (MetS) NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Program) ölçütlerine göre tarandı. Bulgular: Hastaların %36.7’sinde MetS görüldü. AA alt grubunda DD alt grubuna oranla daha yüksek oranda MetS görüldü. Abdominal obesite ikiuçlu bozuklukta leptin seviyeleri ile anlamlı düzeyde ilişkili olarak saptandı. İkiuçlu bozuklukta leptin seviyeleri ve MetS arasında anlamlı bir ilişki bulunamadı. Tartışma: AA kullanan ikiuçlu hastalar yüksek MetS oranlarına sahipti. Bununla birlikte AA’ler arasında MetS sıklığı açısından anlamlı farklılık yoktu. Leptin seviyeleri ikiuçlu hastalarda abdominal obesite ile anlamlı düzeyde ilişkili olmasına karşın MetS ile ilişkili görünmemektedir
Objective: In this study we aimed to evaluate the relationship between serum leptin levels, metabolic syndrome and treatment in bipolar patients. Method: Sixty bipolar I disorder (BD) patients were enrolled; 29 patients were on mood stabilizer (MS) (lithium, valproic acid, carbamazepin, and lamotrigine) treatment, 31 patients were on atypical antipsychotics (AA) (risperidone, quetiapine, and olanzapine) for at least 3 months . Metabolic syndrome (MetS) was evaluated according to NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Programme) criteria. Results: 36.7% of the patients were recognized as MetS. The AA subgroup had significantly more MetS than MS. Abdominal obesity was significantly correlated with leptin levels in BD. No significant association was found between MetS and leptin levels in BD. Discussion: AA taking bipolar patients had higher MetS rates. However, there was no significant difference among AAs for inducing MetS. Leptin levels were significantly correlated with abdominal obesity in bipolar patients but seem not to be associated with MetS.
Objective: In this study we aimed to evaluate the relationship between serum leptin levels, metabolic syndrome and treatment in bipolar patients. Method: Sixty bipolar I disorder (BD) patients were enrolled; 29 patients were on mood stabilizer (MS) (lithium, valproic acid, carbamazepin, and lamotrigine) treatment, 31 patients were on atypical antipsychotics (AA) (risperidone, quetiapine, and olanzapine) for at least 3 months . Metabolic syndrome (MetS) was evaluated according to NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Programme) criteria. Results: 36.7% of the patients were recognized as MetS. The AA subgroup had significantly more MetS than MS. Abdominal obesity was significantly correlated with leptin levels in BD. No significant association was found between MetS and leptin levels in BD. Discussion: AA taking bipolar patients had higher MetS rates. However, there was no significant difference among AAs for inducing MetS. Leptin levels were significantly correlated with abdominal obesity in bipolar patients but seem not to be associated with MetS.
Açıklama
Anahtar Kelimeler
Farmakoloji ve Eczacılık
Kaynak
Klinik Psikofarmakoloji Bülteni
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
2
Künye
Yumru, M., Savaş, E., Gergerlioğlu, H. S., Başaralı, K., Kalenderoğlu, A., Savaş, H. A., Büyükbaş, S. (2008). İkiuçlu bozuklukta metabolik sendrom, serum leptin düzeyleri ve tedavi ilişkisi. Klinik Psikofarmakoloji Bülteni, 18(2), 79-83.
