Solubilizing Effect of the P-Phosphonate Calix[n]arenes Towards Poorly Soluble Drug Molecules Such as Nifedipine, Niclosamide and Furosemide

dc.contributor.authorBayrakçı, Mevlüt
dc.contributor.authorErtul, Şeref
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T18:31:20Z
dc.date.available2020-03-26T18:31:20Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of drug molecules was significantly increased in the presence of calix[n]arene host molecules. The increase in solubility of drugs by the calix[n]arene was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug:cyclodextrin complexes.en_US
dc.description.sponsorshipS.U. Research FoundationSelcuk University [BAP: 10101016]en_US
dc.description.sponsorshipThis study is part of the PhD Thesis of Mevlut Bayrakci and the authors gratefully would like to thank S.U. Research Foundation (BAP: 10101016) for financial support.en_US
dc.identifier.citationBayrakçı, M., Ertul, Ş., Yılmaz, M., (2012). Solubilizing Effect of the P-Phosphonate Calix[n]arenes Towards Poorly Soluble Drug Molecules Such as Nifedipine, Niclosamide and Furosemide. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 74, 415-423. DOI 10.1007/s10847-012-0135-7
dc.identifier.doi10.1007/s10847-012-0135-7en_US
dc.identifier.endpage423en_US
dc.identifier.issn1388-3127en_US
dc.identifier.issn1573-1111en_US
dc.identifier.issue01.04.2020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10847-012-0135-7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28409
dc.identifier.volume74en_US
dc.identifier.wosWOS:000306946700043en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBayrakçı, Mevlüt
dc.institutionauthorErtul, Şeref
dc.institutionauthorYılmaz, Mustafa
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJournal of Inclusion Phenomena and Macrocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalixareneen_US
dc.subjectDrugen_US
dc.subjectNifedipineen_US
dc.subjectNiclosamideen_US
dc.subjectFurosemideen_US
dc.titleSolubilizing Effect of the P-Phosphonate Calix[n]arenes Towards Poorly Soluble Drug Molecules Such as Nifedipine, Niclosamide and Furosemideen_US
dc.typeArticleen_US

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