In vitro and in silico insights of Cupressus sempervirens, Artemisia absinthium and Lippia triphylla: Bridging traditional knowledge and scientific validation

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorMollica, Adriano
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorPicot, Carene Marie Nancy
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T19:41:53Z
dc.date.available2020-03-26T19:41:53Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: The search for new therapeutic agents for the management of diabetes mellitus type 2 (DMT2) and neurodegenerative disorders coupled with the rising number of patients suffering from these pathologies have attracted much interest. Traditionally, extracts from medicinal plants have been used to manage a number of ailments and still remain a potent source of new therapeutic agents. Methods: Therefore, the present study was undertaken to evaluate the in vitro antioxidant and enzyme (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, alpha-amylase, and alpha-glucosidase) inhibitory potential of three medicinal plants (Cupressus sempervirens, Artemisia absinthium, and Lippia triphylla). The phenolic composition of the ethanolic extracts was also characterized using reversed-phase high-performance liquid chromatography (RP-HPLC). In silico molecular docking was used to investigate the possible interaction between active compounds and the studied enzymes. Results: C. sempervirens showed the highest inhibition rates against AChE, BChE, alpha-amylase, and alpha-glucosidase (2.47 mg galantamine equivalents (GALAE)/g extract, 2.98 mg GALAE/g extract, 1.61 mmol acarbose equivalents (ACAE)/g extract, and 1.86 mmol ACAE/g extract for respective enzymes). The plant extracts showed antioxidant power in the following order C. sempervirens > L. triphylla > A. absinthium. Protocatechuic acid, (+)-catechin, apigenin, and chlorogenic acid were identified in all the plant extracts. The best docking pose obtained for each bioactive compound against the enzymes was mostly stabilized via hydrogen bonds and pi-pi stacks. Conclusion: This study provides insight into the antioxidant capacity and the inhibitory potential of these medicinal plants against key enzymes linked to DMT2 and neurodegenerative disorders.en_US
dc.identifier.doi10.1016/j.eujim.2017.05.010en_US
dc.identifier.endpage141en_US
dc.identifier.issn1876-3820en_US
dc.identifier.issn1876-3839en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.eujim.2017.05.010
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35197
dc.identifier.volume12en_US
dc.identifier.wosWOS:000414230000019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofEUROPEAN JOURNAL OF INTEGRATIVE MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCupressus sempervirensen_US
dc.subjectBioactive compoundsen_US
dc.subjectDiabetesen_US
dc.subjectNeurodegenerative disordersen_US
dc.subjectTraditional medicineen_US
dc.subjectAntioxidanten_US
dc.subjectMolecular dockingen_US
dc.subjectLippia triphyllaen_US
dc.titleIn vitro and in silico insights of Cupressus sempervirens, Artemisia absinthium and Lippia triphylla: Bridging traditional knowledge and scientific validationen_US
dc.typeArticleen_US

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