A comparative study of Bulgarian and Turkish Asphodeline lutea root extracts: HPLC-UV profiles, enzyme inhibitory potentials and anti-proliferative activities against MCF-7 and MCF-10A cell lines

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dc.contributor.authorLazarova, Irina
dc.contributor.authorZengin, Gökhan
dc.contributor.authorBender, Onur
dc.contributor.authorZheleva-Dimitrova, Dimitrina
dc.contributor.authorUysal, Şengül
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorGevrenova, Reneta
dc.date.accessioned2020-03-26T19:00:19Z
dc.date.available2020-03-26T19:00:19Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAsphodeline lutea (L.) Rchb. is a wild plant traditionally used as a food in the Mediterranean region. The alcoholic extracts of A. lutea roots from different origins (Bulgarian and 'Rakish) were investigated for anti-cholinesterase, anti-tyrosinase, anti-amylase, anti-glycosidase and anti-proliferative activity (against MCF-7 and MCF-10A cell lines). A validated HPLC method for the determination of two anthraquinones, two bianthraquinones, two naphthalenes, two flavonoids and one hydroxycinnamic acid was developed due to the presence of these components in the genus Asphodeline. In addition, total anthraquinones content was determined spectrophotometrically. A. lutea from Bulgaria demonstrated higher level of total anthraquinones (0.81 +/-0.05 mg g(-1)). A naphthalene derivative (2-acetyl-1,8-dimethoxy-3-methylnaphthalene) was the major compound in Bulgarian accession (0.96 +/- 0.03 mg g(-1)), while caffeic acid was the main analyte in Turkish sample (0.42 +/- 0.06 mg g(-1)). Turkish extracts were more potent as cholinesterase and tyrosinase inhibitors but less active as antidiabetic agent. The higher anti-proliferative effect was presented by Bulgarian extract with IC50 values 120 +/- 16.8 mg mL(-1) (for MCF-7) and 256 +/- 16.1 mg mL(-1) (for MCF-10A). (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jff.2015.03.032en_US
dc.identifier.endpage263en_US
dc.identifier.issn1756-4646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage254en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jff.2015.03.032
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31745
dc.identifier.volume15en_US
dc.identifier.wosWOS:000355240800025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF FUNCTIONAL FOODSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsphodeline luteaen_US
dc.subjectAnthraquinonesen_US
dc.subjectAnti-cholinesteraseen_US
dc.subjectAnti-tyrosinaseen_US
dc.subjectAnti-diabeticen_US
dc.subjectAnti-proliferativeen_US
dc.titleA comparative study of Bulgarian and Turkish Asphodeline lutea root extracts: HPLC-UV profiles, enzyme inhibitory potentials and anti-proliferative activities against MCF-7 and MCF-10A cell linesen_US
dc.typeArticleen_US

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