Thermoresponsive Oligo(ethylene glycol) Methacrylate Colloids with Antifouling Surface Properties

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dc.contributor.authorYavuz, Mustafa Selman
dc.contributor.authorBuyukserin, Fatih
dc.contributor.authorZengin, Zuleyha
dc.contributor.authorCamli, Sevket Tolga
dc.date.accessioned2020-03-26T18:17:19Z
dc.date.available2020-03-26T18:17:19Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThermoresponsive polymeric colloids attract great attention in several biotechnological applications owing to their ability to manipulate drug release characteristics in a controlled manner. Majority of these applications utilized N-isopropylacrylamide (NIPAM)-based particles for controlled drug release. Despite its advantages, such as easy chemical modification and well-documented literature, a potentially important bottleneck for NIPAM in biological applications is its tendency for nonspecific protein adsorption. Herein, we report a simple way to prepare novel thermoresponsive colloids composed of oligo(ethylene glycol) side chains via precipitation polymerization technique. In addition to displaying highly reversible thermal response, these particles also have considerably low nonspecific protein adsorption when compared with NIPAM counterparts. These crosslinked poly(ethylene glycol) ethyl ether methacrylate particles were characterized using dynamic light scattering and transmission electron microscopy. The effects of co-monomer, crosslinker and initiator on particle characteristics were investigated. Finally, particle toxicity studies were carried out using 3T3 fibroblast cell lines in MTT cytotoxicity assay. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 4800-4808, 2011en_US
dc.description.sponsorshipEuropean CommunityEuropean Community (EC) [248819]en_US
dc.description.sponsorshipThis work was partially supported by Marie Curie International Reintegration Grant within the 7th European Community Framework Program, Project No: 248819.en_US
dc.identifier.doi10.1002/pola.24927en_US
dc.identifier.endpage4808en_US
dc.identifier.issn0887-624Xen_US
dc.identifier.issn1099-0518en_US
dc.identifier.issue22en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage4800en_US
dc.identifier.urihttps://dx.doi.org/10.1002/pola.24927
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27011
dc.identifier.volume49en_US
dc.identifier.wosWOS:000296255900011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpoly(ethylene glycol) ethyl ether methacrylateen_US
dc.subjectthermoresponsiveen_US
dc.subjectprecipitation polymerizationen_US
dc.subjectantifoulingen_US
dc.subjectbovine serum albumin adsorptionen_US
dc.titleThermoresponsive Oligo(ethylene glycol) Methacrylate Colloids with Antifouling Surface Propertiesen_US
dc.typeArticleen_US

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