Akut Koroner Sendromların Erken Döneminde Akut Faz Reaktanlarının Belirlenmesi
Yükleniyor...
Dosyalar
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Son yıllarda iskemik kalp hastalıklarının oluşumu ve gelişiminde inflamasyonun rolü birçok klinik ve deneysel çalışmayla yoğun olarak araştırılmaktadır. Akut koroner sendromlar iskemik kalp hastalıklarının patolojik ve klinik olarak en ciddi formudur. Bu çalışmada akut koroner sendromlu olguların acil servise başvuru sonrası ilk 12 saatlik erken dönemindeki inflamasyon belirteçlerinin değişimini araştırdık. Bu amaçla akut miyokard infarktüsü (AMI) ve anstabil angina pektoris (UAP) tanısı konulan olgularda plazma akut faz reaktanlarının [Lipoprotein a (Lp a), beyaz küre, fibrinojen, C-reaktif protein (CRP), kompleman 3 ve 4 (C3, C4)] acil servise başvuru sırasında ve 12 saat sonraki değerleri ölçülerek inflamasyon şiddeti yönünden karşılaştırıldı. Yöntem: Çalışmaya göğüs ağrısı şikayetiyle İlk ve Acil Yardım Kliniği'ne başvurup, fizik muayene ve laboratuar tetkikleri ile UAP (54 hasta) ve AMI (58 hasta) tanısı konulan çalışma grubu ve herhangi bir yakınması bulunmayan sağlıklı gönüllü kontrol grubu (50 birey) dahil edildi. İlk ve Acil Yardım Kliniği'ne kabul edilen çalışma grubundan başvuru anında ve on iki saat sonra, kontrol grubundan ise on iki saat arayla iki kez venöz kan örneği alındı. Bulgular: UAP'li olgularda ilk 12 saatlik dönemde fibrinojen ve C4 değerlerindeki azalma, AMI'lü olgularda lipoprotein (a) değerlerindeki artış anlamlı bulundu (sırasıyla, P0.016, P0.029, P0.047). Sonuç: Akut koroner sendromun her iki formunda da acil servise kabulden sonraki ilk 12 saatlik dönemde inflamatuar süreç devam etmekte, özellikle fibrinojen ve C4 gibi inflamasyon belirteçlerinin plazma değerlerinde azalma görülmektedir.
In recent years many clinical and experimental studies have been carried out to find out the role of inflammation in the pathogenesis and development of the ischemic heart diseases. Acute coronary syndromes are the most serious pathological and clinical forms of ischemic heart diseases. In this article, we studied the changes of inflammation determinants during the first 12 hours after admission of patients with acute coronary syndromes to the emergency service. For this purpose, plasma acute phase reactants [lipoprotein a (Lp a), white blood cell, fibrinogen, c-reactive proteins (CRP), complements 3 and 4 (C3, C4)] of the patients diagnosed as having acute myocardial infarction (AMI) and unstable angina pectoris (UAP) were on arrival at the emergency service and 12 hours later for the severity of inflammation. Methods: Included in this study were the subjects admitted to the First aid and Emergency Service with the complaints of chest pain, and were diagnosed as UAP (54 patients) and AMI (58 patients) by physical examination and laboratory tests as the study group and a control group (50 individuals) of healthy people without any complaint. At the Emergency Service, from study group venous blood samples were taken immediately at admission and after 12 hours, while from control group the samples taken twice every 12 hours. Results: The decrease in the levels of fibrinogen and C4 in cases with UAP during the first 12 hours interval and the increase in lipoprotein (a) level in cases with AMI were statistically significant (respectively, P0.016, P0.029, P0.047). Conclusion: In both types of acute coronary syndromes, inflammatory process continues into the first 12 hour period after the admission to the emergency service, especially there is a decrease in the number of inflammation determinants in plasma such as fibrinogen and C4
In recent years many clinical and experimental studies have been carried out to find out the role of inflammation in the pathogenesis and development of the ischemic heart diseases. Acute coronary syndromes are the most serious pathological and clinical forms of ischemic heart diseases. In this article, we studied the changes of inflammation determinants during the first 12 hours after admission of patients with acute coronary syndromes to the emergency service. For this purpose, plasma acute phase reactants [lipoprotein a (Lp a), white blood cell, fibrinogen, c-reactive proteins (CRP), complements 3 and 4 (C3, C4)] of the patients diagnosed as having acute myocardial infarction (AMI) and unstable angina pectoris (UAP) were on arrival at the emergency service and 12 hours later for the severity of inflammation. Methods: Included in this study were the subjects admitted to the First aid and Emergency Service with the complaints of chest pain, and were diagnosed as UAP (54 patients) and AMI (58 patients) by physical examination and laboratory tests as the study group and a control group (50 individuals) of healthy people without any complaint. At the Emergency Service, from study group venous blood samples were taken immediately at admission and after 12 hours, while from control group the samples taken twice every 12 hours. Results: The decrease in the levels of fibrinogen and C4 in cases with UAP during the first 12 hours interval and the increase in lipoprotein (a) level in cases with AMI were statistically significant (respectively, P0.016, P0.029, P0.047). Conclusion: In both types of acute coronary syndromes, inflammatory process continues into the first 12 hour period after the admission to the emergency service, especially there is a decrease in the number of inflammation determinants in plasma such as fibrinogen and C4
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
2
Künye
Gül, M., Kafalı, M. E., Ak, A., Tokaç, M., Bayır, A., (2002). Akut Koroner Sendromların Erken Döneminde Akut Faz Reaktanlarının Belirlenmesi. Genel Tıp Dergisi, 12(2), 51-55.
