In vivo examination of the effects of hydroxycinnamic acid on xenobiotic metabolizing and antioxidant enzymes

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dc.contributor.authorSemiz, Aslı
dc.contributor.authorTurgut, Gurbet Çelik
dc.contributor.authorKarakurt, Serdar
dc.contributor.authorAkca, Hakan
dc.contributor.authorArslan, Şevki
dc.contributor.authorAdalı, Orhan
dc.contributor.authorŞen, Alaattin
dc.date.accessioned2020-03-26T19:41:53Z
dc.date.available2020-03-26T19:41:53Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the last decade, hydroxycinnamic acids (HCA) have gained increasing attention from researchers due to their antioxidant potential. The aim of this study was to examine in detail the impact of dietary HCA on particular types of P450 and also selected phase II and antioxidant enzymes in Wistar rat. HCA (10 mu M/kg/day, i.p.) was administered for ten continuous days. Examination of the activities and mRNA and protein levels revealed that CYP2B, 2C6 and 3A enzyme activities were not altered significantly, with Western blot and qRT-PCR results corroborating this result. While treatment with HCA led to a significant reduction in CYP1A1/CYP1A2-associated enzyme activities, CYP1A1 protein, and mRNA levels were found to be unchanged. Aromatase (CYP19) activity, as well as protein and mRNA levels, were significantly reduced with HCA treatment. On the other hand, the NAD(P) H: quinone oxidoreductase 1 (NQO1), catalase (CAT), glutathione peroxidase (GPx) and glutathione S-transferases (GSTs) activities were increased significantly. Also, HCA treatment significantly increased the GST-mu and GST-theta mRNA levels.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109R012]en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific and Technological Research Council of Turkey (109R012).en_US
dc.identifier.doi10.2298/ABS160208083Sen_US
dc.identifier.endpage110en_US
dc.identifier.issn0354-4664en_US
dc.identifier.issn1821-4339en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://dx.doi.org/10.2298/ABS160208083S
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35202
dc.identifier.volume69en_US
dc.identifier.wosWOS:000396702900011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherINST BIOLOSKA ISTRAZIVANJA SINISA STANKOVICen_US
dc.relation.ispartofARCHIVES OF BIOLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthydroxycinnamic acidsen_US
dc.subjectdrug-metabolizing enzymesen_US
dc.subjectantioxidant enzymesen_US
dc.subjectchemopreventionen_US
dc.titleIn vivo examination of the effects of hydroxycinnamic acid on xenobiotic metabolizing and antioxidant enzymesen_US
dc.typeArticleen_US

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