Evaluation of Toll-Like Receptor Expression with Clinicopathologic Variables in Endometrium Cancer
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
YERKURE TANITIM YAYINCILIK HIZMETLERI AS
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: Clinical evidence supports the association of toll-like receptor (TLR) with abnormal cell proliferation and cancer. In this study, we investigated the expression of TLRs 2, 4, 5, and 6 in healthy endometrium and endometrium cancer to study the relationship of these receptors' expression with carcinogenesis. Methods: Patients who had undergone a hysterectomy owing to endometrium cancer (group 1, 66 patients), endometrial hyperplasia (group 2, 14 patients), and other reasons besides endometrium cancer (group 3, 20 patients as controls) were included. The cases in the first group were classified by histological type of the cancer, stage, grade, and size of the tumor. In all the cases, expressions of TLRs 2, 4, 5, and 6 were assessed, and the relationship of these receptors with clinicopathologic signs was analyzed. For immunohistochemical staining, nuclear and cytoplasmic stainings were considered positive. A Chi-squared test was used to assess the correlation of the groups. A p<0.05 was considered significant. Results: The mean ages of patients in groups 1, 2, and 3 were 59.8 (range 33-83), 48.3 (range 40-59), and 53.4 (range 38-84) years, respectively. All types of TLRs were highly expressed in both types of endometrium cancer (groups 1 and 2). TLR expression was observed with a ratio of 87.9% in group 1, 100% in group 2, and 35% in group 3. There was a statistically significant association of TLR 2 among the three groups (p=0.000). TLR 6 expression in both group 1 and group 2 was significantly higher than that in the control group (p=0.000, p=0.000, respectively). In addition, TLR 6 was higher in cases with late-stage cancer (p=0.033). Regarding tumor grade and the size of the tumor, no association was found between TLR 2 and TLR 6. Conclusion: TLR 2 and TLR 6 were significantly more expressed in cases with endometrium cancer and endometrial hyperplasia. In addition, the presence of TLR 6 may indicate the presence of late-stage endometrial cancer.
Açıklama
Anahtar Kelimeler
Endometrium, endometrial cancer, toll-like receptor, tumor microenvironment
Kaynak
MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
52
Sayı
3
Künye
Bakbak B. B. G., Ilhan T. T., Pekin, A., Kerimoglu O. S, Yilmaz S. A., Kebapcilar A., Dogan N. U. (2018). Evaluation of Toll-Like Receptor Expression with Clinicopathologic Variables in Endometrium Cancer. MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL, 52(3), 196-200.
