Combined usage of testosterone and nandrolone may cause heart damage

dc.contributor.authorTasgin, Erdal
dc.contributor.authorLok, Sefa
dc.contributor.authorDemir, Nagehan
dc.date.accessioned2020-03-26T18:13:57Z
dc.date.available2020-03-26T18:13:57Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the effects of combined application of testosterone and nandrolone on male rabbits during adolescence period for biochemical values which are indicators of damage to heart, liver and kidney. Seven male New Zealand white rabbits, 60-days old, were used in this study. Testosterone (10 mg/kg) + nandrolone deconoate (10 mg/kg) were injected simultaneously to the rabbits in an intramuscular manner once in 1 week for a period of 12 weeks. Blood samples were taken in 0, 4, 8 and 12 weeks. Serum creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl-transferase, creatinine and blood urea nitrogen were measured with an auto-analyzer. Combined use of testosterone and nandrolone caused (p < 0.05) increase in serum creatine kinase-MB activity, but no statistical changes (p > 0.05) were determined in other parameters. As a result, it can be concluded that the use of testosterone plus nandrolone simultaneously during early ages may cause heart damage.en_US
dc.identifier.endpage3768en_US
dc.identifier.issn1684-5315en_US
dc.identifier.issue19en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3766en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26242
dc.identifier.volume10en_US
dc.identifier.wosWOS:000290668200016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherACADEMIC JOURNALSen_US
dc.relation.ispartofAFRICAN JOURNAL OF BIOTECHNOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTestosteroneen_US
dc.subjectnandroloneen_US
dc.subjectcreatine kinase-MBen_US
dc.titleCombined usage of testosterone and nandrolone may cause heart damageen_US
dc.typeArticleen_US

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