Metabolomics-based profiling with chemometric approach to delineate the bio-pharmaceutical properties of fruit extracts from Ligustrum vulgare L

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dc.contributor.authorRocchetti, Gabriele
dc.contributor.authorSenizza, Biancamaria
dc.contributor.authorZengin, Gökhan
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorSadeer, Nabeelah Bibi
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorLucini, Luigi
dc.date.accessioned2020-03-26T20:15:11Z
dc.date.available2020-03-26T20:15:11Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractLigustrum vulgare L. (Family: Oleaceae) is an evergreen shrub native to North-west Africa, Europe and Western Asia. In the present work, infusion (water), ethyl acetate, methanol and n-hexane extracts of the fruits of L. vulgare L. were studied for their in vitro antioxidant and enzyme inhibitory properties along with their untargeted polyphenolic profile (using an ultra-high-performance liquid chromatography-quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry approach). Untargeted metabolomics coupled to multivariate statistics showed that Ligustrum fruit extracts were very abundant in polyphenols, such as flavonoids, tyrosols and lignans, with ethyl acetate allowing the highest recovery among the extraction solvents tested. The methanolic extract inhibited the highest acetylcholinesterase (AChE), tyrosinase and glucosidase activity (4.23 mg galatamine equivalent (GALAE)/g, 132.85 mg kojic acid equivalent (KAE)/g and 1.94 mmol acarbose equivalent (ACAE)/g respectively) while the ethyl acetate extract inhibited the highest butyrylcholinesterase (BChE) and amylase activity (4.92 mg GALAE/g and 0.73 mmol ACAE/g, respectively). However, the infusion showed the weakest activity against all the enzymes studied. However, the extract showed highest antioxidant property in'the antioxidant assays (except for phosphomolybdenum). The present paper is the first comprehensive report on L. vulgare fruits and thus our findings are of considerable interest to design new bioproducts for the pharmaceutical and cosmeceutical industry in the future.en_US
dc.identifier.citationRocchetti, G., Senizza, B., Zengin, G., Şenkardeş, İ., Sadeer, N. B., Mahomoodally, M. F., Lucini, L. (2019). Metabolomics-Based Profiling with Chemometric Approach to Delineate the Bio-Pharmaceutical Properties of Fruit Extracts from Ligustrum vulgare L. Industrial Crops and Products, 140, 111635.
dc.identifier.doi10.1016/j.indcrop.2019.111635en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.111635
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37997
dc.identifier.volume140en_US
dc.identifier.wosWOS:000491621900028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLigustrumen_US
dc.subjectBioactive compoundsen_US
dc.subjectMetabolomicsen_US
dc.subjectMultivariate statisticsen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.titleMetabolomics-based profiling with chemometric approach to delineate the bio-pharmaceutical properties of fruit extracts from Ligustrum vulgare Len_US
dc.typeArticleen_US

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