Evaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patients

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dc.contributor.authorGonul, Saban
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorOzturk, Banu Turgut
dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorSahin, Alparslan
dc.date.accessioned2020-03-26T18:14:35Z
dc.date.available2020-03-26T18:14:35Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To evaluate retinal nerve fiber layer (RNFL) thickness changes of type 1 diabetes mellitus (DM) patients with and without diabetic retinopathy (DR). Material and Methods: One hundred-eighteen patients with type 1 DM and 49 age-matched control subjects were enrolled in the study. Ninety eight of 118 diabetic patients with DR were assigned as group 1 and the remaining 20 patients without DR were labeled as group 20 (n = 98). The RNFL thickness of all subjects were measured using optical coherence tomography (OCT). Results: The study included 118 type 1 DM patients with a mean age of 18.77 +/- 8.80 years. The mean age of 49 subjects in the control group was 18.71 +/- 5.72 (range 7-40) years. The mean RNFL thickness was 103.79 +/- 6.45 mu m in the control group, 100.00 +/- 11.93 mu m in group 1 and 85.59 +/- 19.81 mu m in group 2. The decrease in group 2 was found statistically significant (p < 0.001). The mean RNFL thickness in the superior, nasal, inferior and temporal quadrants were less in group 1 compared to controls, however this data was not statistically significant (p = 0.274, p = 0.149, p = 0326, p = 0783, respectively). In group 2, the RNFL thickness revealed a statistically significant decrease in all quadrants (p < 0.001) except temporal quadrant (p = 0.396). The mean duration of DM was significantly longer in group 2 (153.80 +/- 70.35) compared to group 1(60.76 +/- 50.41 months) (p < 0.001). However, there was no correlation between the RNFL thickness and the duration of DM. Conclusion: The RNFL thickness of patients with type 1 DM was found less compared to control subjects. This was more prominent in patients with established retinopathy (group 2). These findings suggested that the RNFL thickness measurement with the aid of OCT may be used as an adjunctive diagnostic tool for early diagnosis of DR.en_US
dc.identifier.doi10.5336/medsci.2010-20470en_US
dc.identifier.endpage1105en_US
dc.identifier.issn1300-0292en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1100en_US
dc.identifier.urihttps://dx.doi.org/10.5336/medsci.2010-20470
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26468
dc.identifier.volume31en_US
dc.identifier.wosWOS:000297434700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherORTADOGU AD PRES & PUBL COen_US
dc.relation.ispartofTURKIYE KLINIKLERI TIP BILIMLERI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiabetes mellitusen_US
dc.subjecttype 1en_US
dc.subjectdiabetic retinopathyen_US
dc.subjecttomographyen_US
dc.subjectoptical coherenceen_US
dc.titleEvaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patientsen_US
dc.typeArticleen_US

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