In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca

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dc.contributor.authorGrochowski, Daniel M.
dc.contributor.authorUysal, Şengül
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorGranica, Sebastian
dc.contributor.authorZengin, Gökhan
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorLocatelli, Marcello
dc.date.accessioned2020-03-26T19:41:53Z
dc.date.available2020-03-26T19:41:53Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.descriptionInternational Symposium on Chromatography of Natural Products (ISCNP) -- 2016 -- Lublin, POLANDen_US
dc.description.abstractThe genus Potentilla is interesting for the pharmaceutical field due to its valuable medicinal properties, which have been observed in complementary and alternative medicine. In recent years, studies conducted to estimate the biological activity of several of the Potentilla species have shown a wide spectrum of therapeutic properties. In particular, in the present paper, different extracts obtained from the herb P. thuringiaca were analysed for antioxidant and enzyme inhibitory activities. The UHPLC-DADMS3 hyphenated techniques reported herein allow for the identification of phytoconstituents. The analyses showed the presence of flavonoids and ellagitannins as major components. Furthermore, the data demonstrated that the analysed extracts revealed a high total antioxidant capacity in the phosphomolybdenum assay. The free radical scavenging activity of the extracts was evaluated using DPPH and ABTS assays. The reducing power activity of P. thuringiaca was also determined by FRAP and CUPRAC assays, as well as metal chelating activity. In addition, the total extracts and the different fractions of P. thuringiaca revealed potent inhibitory activities against a-amylase and a-glucosidase, AChE, tyrosinase and lipase. Surprisingly, no activity against BChE was shown. P. thuringiaca could be a valuable natural source of antioxidants with interesting inhibitory actions against the key enzymes involved in several human diseases, and could represent a valid starting point for the development of new treatment and management strategies, including its use as a food supplement. (C) 2017 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipMedical University of Bialystok [POPW. 01.03.00-20-001/12]; European Regional Development FundEuropean Union (EU)en_US
dc.description.sponsorshipThis study was financially supported and conducted with the use of equipment by the Medical University of Bialystok as part of OP DEP 2007-2013, Priority Axis I. 3, contract no. POPW. 01.03.00-20-001/12. This project was also carried out with the use of CePT (Medical University of Warsaw) infrastructure financed by the European Regional Development Fund within the Operational Programme "Innovative economy" for 2007-2013.en_US
dc.identifier.doi10.1016/j.phytol.2017.03.005en_US
dc.identifier.endpage372en_US
dc.identifier.issn1874-3900en_US
dc.identifier.issn1876-7486en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage365en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.phytol.2017.03.005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35199
dc.identifier.volume20en_US
dc.identifier.wosWOS:000405467600068en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofPHYTOCHEMISTRY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPotentilla thuringiacaen_US
dc.subjectRosaceaeen_US
dc.subjectAntioxidant activityen_US
dc.subjectEnzyme inhibitory activityen_US
dc.subjectUHPLC-DAD-MS phytochemical profileen_US
dc.subjectHyphenated techniquesen_US
dc.titleIn vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiacaen_US
dc.typeArticleen_US

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