Pharmacokinetics of flunixin-meglumin following intravenous administration in Angora rabbits

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dc.contributor.authorElmas, M
dc.contributor.authorUney, K
dc.contributor.authorKarabacak, A
dc.contributor.authorYazar, E
dc.date.accessioned2020-03-26T16:57:42Z
dc.date.available2020-03-26T16:57:42Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe pharmacokinetics of flunixin-meglumin were determined after intravenous bolus injection at two different doses (1.1 and 2.2 mg/kg body weight) in rabbits. Six healthy adult Angora rabbits were used in the experiment. Blood samples were collected at 10, 20, 30, 45 and 60 min, 2, 4, 6, and 8 h after injection. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were described by a two-compartment open model. The area under the curve, contrary to other pharmacokinetic parameters, showed statistically significant differences between the two doses used (P < 0.05). The data obtained for the low and high doses were as follows: the elimination half-lives were 1.4 and 1.7 h, the volume of distribution - 0.6 and 0.8 L/kg, and total body clearance - 0.32 and 037 mL/h/kg body weight, respectively. The present study has shown that the pharmacokinetic variables of fluxin-meglumin in Angora rabbits are dose independent in the dose range of 1.1-2.2 mg/kg body weight.en_US
dc.identifier.endpage88en_US
dc.identifier.issn0042-4870en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19833
dc.identifier.volume49en_US
dc.identifier.wosWOS:000228098700016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNATL VETERINARY RESEARCH INSTen_US
dc.relation.ispartofBULLETIN OF THE VETERINARY INSTITUTE IN PULAWYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectrabbitsen_US
dc.subjectflunixin-megluminen_US
dc.subjectpharmacokineticsen_US
dc.titlePharmacokinetics of flunixin-meglumin following intravenous administration in Angora rabbitsen_US
dc.typeArticleen_US

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