Ajuga chamaecistus subsp scoparia (Boiss.) Rech.f.: A new source of phytochemicals for antidiabetic, skin-care, and neuroprotective uses

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dc.contributor.authorMovahhedin, Nasrin
dc.contributor.authorZengin, Gökhan
dc.contributor.authorBahadori, Mir Babak
dc.contributor.authorSarıkürkcü, Cengiz
dc.contributor.authorBahadori, Shahram
dc.contributor.authorDinparast, Leila
dc.date.accessioned2020-03-26T19:23:01Z
dc.date.available2020-03-26T19:23:01Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe genus Ajuga is used traditionally as food and medicine. The aim of this study was to investigate the antidiabetic, anti-Alzheimer's diseases, skin-protective, and antioxidant activities of essential oil and extracts of Ajuga chamaecistus subsp. scoparia (Boiss.) Rech.f., together with the identification of their chemical composition. The 1,1-dipheny1-2-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazloine-6-sulfonic acid) radical cation scavenging activity, metal chelating activity, reducing power, content of total bioactive compounds, general toxicity, and enzyme inhibitory potential of essential oil, ethanol extract, and water decoction of the plant were evaluated. Phenolics profile of the extracts was analyzed using the reverse-phase high-performance liquid chromatography with diode array detector and the chemical composition of the essential oil was determined using the gas chromatography and gas chromatography mass spectroscopy techniques. The essential oil could significantly inhibit the activity of alpha-glucosidase (4.3 mmol Acarbose equivalents/g), alpha-amylase (2.8 mmol Acarbose equivalents/g), acetylcholinesterase (1.96 mg gallic acid equivalents/g), butyrylcholinesterase (2.2 mg gallic acid equivalents/g), and tyrosinase (36 mg kojic acid equivalents/g) while ethanol and water extracts showed moderate enzyme inhibitory activity. Furthermore, essential oil had the strongest antioxidant capacity in the 1,1-diphenyl-2-picrylhydrazyl scavenging, 2,2-azino-bis (3ethylbenzothiazloine-6-sulfonic acid) scavenging, cupric reducing antioxidant capacity, ferric reducing antioxidant power, and metal chelating assays. Spathulenol (18.0%), thymol (15.1%), octen-3-ol (14.3%), and linalool oxide (11.2%) were identified as major constituents in the essential oil. Quantitative highperformance liquid chromatography analysis indicated that p-coumaric acid, gallic acid, and ferulic acid are the main phenolic compounds in this plant. The results suggested that Ajuga chamaecistus could be useful for several applications as functional foods, cosmetics, and pharmaceuticals. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipUrmia University of Medical Sciences [1394-01-36-2083]en_US
dc.description.sponsorshipThis work was supported by Urmia University of Medical Sciences through project 1394-01-36-2083.en_US
dc.identifier.doi10.1016/j.indcrop.2016.08.028en_US
dc.identifier.endpage96en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2016.08.028
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33230
dc.identifier.volume94en_US
dc.identifier.wosWOS:000387298100008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAjugaen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectDiabetes mellitusen_US
dc.subjectThymolen_US
dc.subjectCarvacrolen_US
dc.subjectTyrosinaseen_US
dc.titleAjuga chamaecistus subsp scoparia (Boiss.) Rech.f.: A new source of phytochemicals for antidiabetic, skin-care, and neuroprotective usesen_US
dc.typeArticleen_US

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