Calix[4]arene based a NIR-fluorescent sensor with an enhanced stokes shift for the real-time visualization of Zn(II) in living cells

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dc.contributor.authorErdemir, Serkan.
dc.contributor.authorMalkondu, Sait.
dc.date.accessioned2020-03-26T20:20:09Z
dc.date.available2020-03-26T20:20:09Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractZinc(II) plays key roles actively involved in fundamental biological functions in the body. However, zinc dysmetabolism results in a number of human diseases. Therefore, miscellaneous techniques are needed to understand the complete biological role of Zn(II) in tissues and cells. Here, we introduce a novel calix[4]arene derivative (CIP), appended with two isophorone units via a 4-bromophenol linker for the fluorescence sensing Zn (II). CIP showed high fluorogenic selectivity for Zn(II) over a wide range of biologically and environmentally relevant metal ions in DMSO/H2O (v/v, 8/2, PBS buffer, 0.5 mM, pH 7.4) and has superior sensitivity of (6.75 nM) for Zn(II). Free CIP has very low emission but demonstrated the distinct "turn-on" emission enhancement response toward Zn(II) at near infrared region. CIP allowed the fabrication of a rapid and convenient TLC strip sensor for Zn(II)-selective detection. Moreover, this is the first report on a calix[4]are derivative used as a NIR fluorescence probe that monitors changes in intracellular Zn(II) levels and can penetrate into living cells.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk University; Biochemistry Department of Selcuk University-Turkeyen_US
dc.description.sponsorshipAuthors are thankful to the Research Foundation of Selcuk University (BAP) for financial assistance. Also, we acknowledge the help from Assoc. Prof. Serdar Karakurt, Biochemistry Department of Selcuk University-Turkey, in living cell imaging studies.en_US
dc.identifier.citationErdemir, S., Malkondu, S. (2020). Calix[4]arene Based a NIR-fluorescent Sensor with an Enhanced Stokes Shift for the Real-time Visualization of Zn(II) in Living Cells. Sensors and Actuators B: Chemical, 306, 1-8.
dc.identifier.doi10.1016/j.snb.2019.127574en_US
dc.identifier.endpage8
dc.identifier.issn0925-4005en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1016/j.snb.2019.127574
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38515
dc.identifier.volume306en_US
dc.identifier.wosWOS:000507459500008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorErdemir, Serkan.
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE SAen_US
dc.relation.ispartofSENSORS AND ACTUATORS B-CHEMICALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNIRen_US
dc.subjectFluorescenceen_US
dc.subjectSensoren_US
dc.subjectBioimagingen_US
dc.subjectZincen_US
dc.titleCalix[4]arene based a NIR-fluorescent sensor with an enhanced stokes shift for the real-time visualization of Zn(II) in living cellsen_US
dc.typeArticleen_US

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