Effects of single dose administered nandrolone decanoate on serum cytokine levels and some biochemical parameters in male and female rats.

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dc.contributor.authorTasgin, Erdal
dc.contributor.authorLok, Sefa
dc.contributor.authorHaliloglu, Seyfullah
dc.contributor.authorDemir, Nagehan
dc.contributor.authorErgin, Hale
dc.date.accessioned2020-03-26T19:35:24Z
dc.date.available2020-03-26T19:35:24Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim this this study was to determine that administration of single higher dose nandrolone decanoate (40 mg/kg) on serum IL-1 beta, TNF-alpha, IL-10 and IL-6 levels and some biochemical parameters during 24 h in male and female rats. The blood samples were taken from 5 male and female rats to obtain their starting values. Then the blood samples were taken from 6 rats in sampling time at 1st, 2nd, 4th, 8th, 12th and 24th h following the nandrolone decanoate administration. There were significant increases determined in the serum IL-1 beta levels, numerical increases in the TNF-alpha levels whereas decreased IL-6 levels were determined. IL-10 levels did not change during experimental period. While serum GGT and BUN levels increased towards the last h of the study, increased ALP levels were observed only female rats. There was no any significance changes were determined in the other biochemical (ALT, AST, CK-MB and LDH) values. As a result, increased IL-1 beta and TNF-alpha levels, proinflammatory cytokines, and some biochemical parameters may be reflect that long term used nandrolone decanoate causes organ damages and effect immune system function. However, effects of long term used nandrolone decanoate on the immune system and organ functions should be detailed evaluated.en_US
dc.description.sponsorshipSUBAPKSelcuk University [10401125]en_US
dc.description.sponsorshipThis study was supported by the scientific research coordinator SUBAPK (10401125). A part of the abstract was presented at the "13th International Congress of sport sciences" 07-9 November 2014, Konya, Turkey.en_US
dc.identifier.endpage3730en_US
dc.identifier.issn0970-938Xen_US
dc.identifier.issn0976-1683en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3727en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35046
dc.identifier.volume28en_US
dc.identifier.wosWOS:000403454800073en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSCIENTIFIC PUBLISHERS INDIAen_US
dc.relation.ispartofBIOMEDICAL RESEARCH-INDIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNandroloneen_US
dc.subjectCytokinesen_US
dc.subjectOrgan damagesen_US
dc.titleEffects of single dose administered nandrolone decanoate on serum cytokine levels and some biochemical parameters in male and female rats.en_US
dc.typeArticleen_US

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