Stevens-Johnson Syndrome-Like Exanthema Secondary to Methotrexate

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorÇalışkan, Ümran
dc.contributor.authorPirgon, Özgür
dc.contributor.authorTol, Hüseyin
dc.contributor.authorErkul, İbrahim
dc.date.accessioned2020-03-26T16:45:02Z
dc.date.available2020-03-26T16:45:02Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMethotrexate is an antineoplastic drug used commonly in leukemia treatment. Because of becoming resistant to standard doses after 1970s, it is used intermediate or high doses. The complications of high doses are mucositis, vomiting, dermatitis exfoliativa, B-cell dysfunction, hepatotoxicity, nephrotoxicity and bone marrow depression. There were only two studies in literature about Stevens-Johnson syndrome occuring in two patients with acute lymphocytic leukemia and non-Hodgkin lymphoma after receiving high doses methotrexate and leukoverin. We have reported a two-year-old boy patient suffering from acute lymphocytic leukemia (ALL) developed a severe skin reaction two days after administration of high dose methotrexate. The skin lesions simulated Stevens-Johnson syndrome with ulceration of the oral mucosa and erythema multiforme-like target lesions.en_US
dc.identifier.citationAtabek, M. E., Çalışkan, Ü., Pirgon, Ö., Tol, H., Erkul, İ., (2002). Stevens-Johnson Syndrome-Like Exanthema Secondary to Methotrexate. Turkish Journal of Haematology, 19(3), 427-430.
dc.identifier.endpage430en_US
dc.identifier.issn1300-7777en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage427en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18173
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAtabek, Mehmet Emre
dc.institutionauthorÇalışkan, Ümran
dc.institutionauthorPirgon, Özgür
dc.institutionauthorTol, Hüseyin
dc.institutionauthorErkul, İbrahim
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Haematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute lymphocytic leukemia (ALL)en_US
dc.subjectMethotrexateen_US
dc.subjectStevens-Johnson syndromeen_US
dc.titleStevens-Johnson Syndrome-Like Exanthema Secondary to Methotrexateen_US
dc.typeArticleen_US

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