Facile synthesis of boronic acid-functionalized nanocarriers for glucose-triggered caffeic acid release

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dc.contributor.authorUlasan, Mehmet
dc.contributor.authorYavuz, Emine
dc.contributor.authorCengeloglu, Yunus
dc.contributor.authorYavuz, Mustafa Selman
dc.date.accessioned2020-03-26T19:05:59Z
dc.date.available2020-03-26T19:05:59Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, boronic acid-functionalized methacrylate-based nanoparticles were synthesized via surfactant-free emulsion polymerization in one pot. Uniform (polydispersity index < 0.05) sub-100 nm nanoparticles were obtained. The changes of average hydrodynamic diameter and polydispersity index of nanoparticles against boronic acid content in total monomer and acetone percentage in the solvent mixture were investigated. Polymerization kinetics in terms of monomer conversion rate was monitored by gravimetric method. The nanoparticles were characterized by scanning electron microscopy and dynamic light scattering. The boron content in the nanoparticles was confirmed by electron-dispersive X-ray spectroscopy. Further, the nanoparticles were combined with caffeic acid. Caffeic acid carrying nanoparticles were titrated against glucose or fructose in which caffeic acid is released by the displacement reaction in a controlled manner. The displacement of caffeic acid and glucose was monitored by UV-visible spectral change. Furthermore, in vitro biocompatibility of nanoparticles was tested in NIH-3T3 cells, which resulted no significant toxicity effect on the cells.en_US
dc.description.sponsorshipSelcuk University Scientific Research Fund (S.U. BAP)Selcuk University [12201077]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112M096, COST TD1004]en_US
dc.description.sponsorshipThis work was supported by Selcuk University Scientific Research Fund (S.U. BAP No. 12201077) and TUBITAK (Project No.112M096, COST TD1004). The authors are grateful to Advanced Technology Research and Application Center of Selcuk University for their kind help regarding with analysis studies (SEM, EDX, DLS, UV-Vis). The authors thank to Dr. Pembegul UYAR for providing 3T3 cells as a kind gift and her valuable guidance and to Huseyin Sakalak for his help in experimental studies.en_US
dc.identifier.doi10.1007/s00289-015-1393-5en_US
dc.identifier.endpage2142en_US
dc.identifier.issn0170-0839en_US
dc.identifier.issn1436-2449en_US
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2127en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00289-015-1393-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32154
dc.identifier.volume72en_US
dc.identifier.wosWOS:000359832200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPOLYMER BULLETINen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCaffeic aciden_US
dc.subjectGlucose-responsive nanoparticlesen_US
dc.subjectDrug deliveryen_US
dc.subjectSmart nanomaterialsen_US
dc.subjectSurfactant-free emulsion polymerizationen_US
dc.titleFacile synthesis of boronic acid-functionalized nanocarriers for glucose-triggered caffeic acid releaseen_US
dc.typeArticleen_US

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