Effects of Nimodipine on Tissue Lactate and Malondialdeyde Levels in Experimental Head Trauma

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dc.contributor.authorAk, A.
dc.contributor.authorÜstün, M. E.
dc.contributor.authorOgün, C. O.
dc.contributor.authorDuman, A.
dc.contributor.authorBor, M. A.
dc.date.accessioned2020-03-26T16:37:07Z
dc.date.available2020-03-26T16:37:07Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe studied the effects of nimodipine on brain tissue lactate and malondialdehyde (MDA) levels one hour after experimental head trauma in 25 New Zealand rabbits. Group 1(n=5) was the sham operated group. Group 2 (n=10) received head trauma without treatment and in group 3 (n=10) nimodipine was administered for 30 minutes intravenously (2 mug/kg/min) immediately after head trauma. In groups 2 and 3, tissue samples from the nontraumatized side was named as "a" and traumatized side as "b". The lactate and malondialdehyde contents were significantly higher in groups 2a, 2b, 3a and 3b when compared with to group 1 (P <0.05). The differences between non-treated groups (2a, 2b) and nimodipine treated groups (3a, 3b) were not significant (P >0.05). The differences between the traumatized sides (2b, 3b) and non-traumatized sides (2a, 3a) were significant (P <0.05). These results demonstrated that nimodipine is ineffective in suppressing the increase of tissue lactate and malondialdehyde levels in the early period of experimental head trauma.en_US
dc.identifier.citationAk, A., Üstün, M. E., Ogün, C. O., Duman, A., Bor, M. A., (2001). Effects of Nimodipine on Tissue Lactate and Malondialdeyde Levels in Experimental Head Trauma. Anaesthesia and Intensive Care, 29(5), 484-488. Doi: 10.1177/0310057X0102900506
dc.identifier.doi10.1177/0310057X0102900506en_US
dc.identifier.endpage488en_US
dc.identifier.issn0310-057Xen_US
dc.identifier.issn1448-0271en_US
dc.identifier.issue5en_US
dc.identifier.pmid11669428en_US
dc.identifier.startpage484en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0310057X0102900506
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17541
dc.identifier.volume29en_US
dc.identifier.wosWOS:000171471600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAk, A.
dc.institutionauthorÜstün, M. E.
dc.institutionauthorOgün, C. O.
dc.institutionauthorDuman, A.
dc.institutionauthorBor, M. A.
dc.language.isoenen_US
dc.publisherAustralian Soc Anaesthetistsen_US
dc.relation.ispartofAnaesthesia and Intensive Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthead traumaen_US
dc.subjectlactate
dc.subjectlipid peroxidation
dc.subjectmalondialdehyde
dc.subjectnimodipine
dc.titleEffects of Nimodipine on Tissue Lactate and Malondialdeyde Levels in Experimental Head Traumaen_US
dc.typeArticleen_US

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