Total Phenolics, Flavonoids, Condensed Tannins Content of Eight Centaurea Species and Their Broad Inhibitory Activities against Cholinesterase, Tyrosinase, alpha-Amylase and alpha-Glucosidase

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorCarradori, Simone
dc.contributor.authorMocan, Andrei M.
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T19:31:46Z
dc.date.available2020-03-26T19:31:46Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSeveral bioactive compounds originate from natural sources and their uses are generally related with traditional or folk medicine. Synthetic drugs can have adverse side effects and, for this reason, the investigation of novel, safe, and natural-occurring products can account for the development of new drugs. The genus Centaurea L. is one of the most important genera of the Asteraceae family, containing more than 200 species in the Turkish flora, about 140 of which are endemic. The aim of the present work was to determine enzyme inhibitory potentials of two extracts (chloroform and ethyl acetate) from eight Centaurea species against cholinesterase, tyrosinase, amylase, and glucosidase. The total phenolics, flavonoids and condensed tannin contents were also reported for each extract. These components in the extracts varied according to species and extraction solvents as well as enzyme inhibitory effects. The highest level of phenolics was found to be in the chloroform extract of C. pulchella (119.23 mg GAEs/g extract). Generally, chloroform extracts exhibited stronger enzyme inhibitory effects as compared to ethyl acetate. Additionally, possible correlations with total phenolics, flavonoids, and condensed tannins content were also highlighted. This paper is the first report of the inhibitory capacities of the eight Centaurea species on the selected enzymes. The present results may be a valuable starting point in the development of new bioactive formulations.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support given for this research from the Selcuk University.en_US
dc.identifier.doi10.15835/nbha44110259en_US
dc.identifier.endpage200en_US
dc.identifier.issn0255-965Xen_US
dc.identifier.issn1842-4309en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://dx.doi.org/10.15835/nbha44110259
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34153
dc.identifier.volume44en_US
dc.identifier.wosWOS:000378173900029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUNIV AGR SCI & VETERINARY MED CLUJ-NAPOCAen_US
dc.relation.ispartofNOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectnatural productsen_US
dc.subjectbioactive compoundsen_US
dc.subjectenzyme inhibitionen_US
dc.subjectTurkeyen_US
dc.titleTotal Phenolics, Flavonoids, Condensed Tannins Content of Eight Centaurea Species and Their Broad Inhibitory Activities against Cholinesterase, Tyrosinase, alpha-Amylase and alpha-Glucosidaseen_US
dc.typeArticleen_US

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