Characterization of focal liver lesions: Use of mangafodipir trisodium (MnDPDP)-enhanced MR images
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Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Karaciğer lezyonlarının saptanması ve karakterizasyonunda mangofodipir trisodyum kullanımının etkinliğini değerlendirmek. Yöntem: Karaciğerde lezyonu olan 51 hasta [13 he-patoselüler karsinom , 18 metastaz, 14 hemanjiom, 3 kolanji-oselüler karsinom , 2 kist hidatik ve 1 fokal noduler hiperplazi kontratsız ve mangofodipir trisodyum kontrastlı MRG ile incelendi. Bulgular: Yavaş intravenöz infüzyonla mangofodipir trisodyum sonrası MRG incelemeleri infüzyondan 15-30 dk ve 24 saat sonra yapıldı. Kontrastlanma tüm hepatoselüler lezyon-larda (hepatoselüler karsinom ve fokal noduler hiperplazi) ve normal karaciğer parankiminde görüldü. Hepatoselüler karsi-nomlu hastaların lezyonlarında inhomojen kontrastlanma pa-terni görüldü. Nonhepatoselüler lezyonlarda (hemanjiom, metastaz, kolanjioselüler karsinom) mangofodipir trisodyum kontrastlı MRG incelemede kontrastlanma olmadı, kolanjioselüler karsinomlu tüm hastalarda, 14 metastaz ve 11 hemanjiomlu hastada rim benzeri kontrastlanma paterni saptandı. Sonuç: Mangofodipir trisodyum kontrastlı MRG, hepatoselüler ve nan-hepatoselüler tümörlerin güvenli bir şekilde ayırt edilmesine olanak sağlar, mangofodipir trisodyum kontrastlı MRG hepatoselüler lezyonların fonksiyonları ve morfolojik durumlarını gösterebilir. Bazı nonhepatoselüler lezyonlar kontrastsız MRG ile tanımlanamaz iken, kontrastlı incelemede vizüalize edilebilirler. Rim tarzı kontrastlanma metastazlar için spesifik değildir, mangofodipir trisodyum kontrastlı MRG güvenilir ve iyi to-lere edilir, karaciğer lezyonlarının noninvaziv tanısında yardımcı olabilecek bir inceleme yöntemidir.
Background/aims: We evaluated the characterization and detection of liver lesions using mangafodipir trisodium. Methods: A total of 51 patients with liver lesions [13 hepatocellular carcinomas , 18 metastases, 14 hemangiomas, three cholangiocellular carcinomas, two hydatic cysts, and one focal nodular hyperplasia (FNH)] were examined by unenhanced and mangafodipir trisodium -enhanced MRI. Results: After administration of mangafodipir trisodium by slow intravenous infusion, mangafodipir trisodium -enhanced MRI was performed at 15- 30 min and 24 h. The enhancement appeared in normal liver parenchyma and all of the hepatocellular lesions (HCCs and FNH). The lesions in hepatocellular carcinomas patients showed a non-homogeneous enhancement pattern. Non-hepatocellular lesions (hemangiomas, metastases, CCCs) had no enhancement on mangafodipir trisodium -enhanced MRI examinations. The rim-like enhancement pattern was demonstrated in all patients with cholangiocellular carcinomas, and in 14 metastases and 11 hemangiomas. Conclusions: Mangafodipir trisodium -enhanced MRI permits reliable distinction between hepatocellular and non-hepatocellular tumors. Mangafodipir trisodium -enhanced MRI can show more functional and morphologic features of hepatocellular lesions. Some non-hepatocellular lesions which went undetected on unenhanced MRI were visualized after contrast enhancement of the liver. The rim-like enhancement pattern is not specific for metastases. Mangafodipir trisodium -enhanced MRI is safe and well tolerated and may aid in noninvasive diagnosis of liver lesions.
Background/aims: We evaluated the characterization and detection of liver lesions using mangafodipir trisodium. Methods: A total of 51 patients with liver lesions [13 hepatocellular carcinomas , 18 metastases, 14 hemangiomas, three cholangiocellular carcinomas, two hydatic cysts, and one focal nodular hyperplasia (FNH)] were examined by unenhanced and mangafodipir trisodium -enhanced MRI. Results: After administration of mangafodipir trisodium by slow intravenous infusion, mangafodipir trisodium -enhanced MRI was performed at 15- 30 min and 24 h. The enhancement appeared in normal liver parenchyma and all of the hepatocellular lesions (HCCs and FNH). The lesions in hepatocellular carcinomas patients showed a non-homogeneous enhancement pattern. Non-hepatocellular lesions (hemangiomas, metastases, CCCs) had no enhancement on mangafodipir trisodium -enhanced MRI examinations. The rim-like enhancement pattern was demonstrated in all patients with cholangiocellular carcinomas, and in 14 metastases and 11 hemangiomas. Conclusions: Mangafodipir trisodium -enhanced MRI permits reliable distinction between hepatocellular and non-hepatocellular tumors. Mangafodipir trisodium -enhanced MRI can show more functional and morphologic features of hepatocellular lesions. Some non-hepatocellular lesions which went undetected on unenhanced MRI were visualized after contrast enhancement of the liver. The rim-like enhancement pattern is not specific for metastases. Mangafodipir trisodium -enhanced MRI is safe and well tolerated and may aid in noninvasive diagnosis of liver lesions.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Cilt
17
Sayı
3
Künye
Karabacakoğlu, A., Adıgüzel, Y., Karaköse, S., Kayaçetin, E., Haykır, Rahime. (2006). Characterization of focal liver lesions: Use of mangafodipir trisodium (MnDPDP)-enhanced MR images. Turkish Journal of Gastroenterology, 17(3), 164-171.
