Phase Solubility Studies of Poorly Soluble Drug Molecules by Using O-Phosphorylated Calixarenes as Drug-Solubilizing Agents

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dc.contributor.authorBayrakçı, Mevlüt
dc.contributor.authorErtul, Şeref
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T18:31:01Z
dc.date.available2020-03-26T18:31:01Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study is the first report on the solubilizing effect of O-phosphorylated calix[n]arenes that form complexes with neutral molecules such as nifedipine, niclosamide, and furosemide by host-guest complexation. These complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of guest molecules such as nifedipine, niclosamide, and furosemide was significantly increased in the presence of host molecules tetrakis-O-(diethoxyphosphoryl)-p-tert-butylcalix[4]arene (1), tetrakis-O-(diethoxyphosphoryl)-calix[4]arene (2), bis-O-(diethoxyphosphoryl)-p-tert-butylcalix[4]arene (3), bis-O-(diethoxyphosphoryl)-calix[4]arene (4), and octakis-O-(diethoxyphosphoryl)-p-tert-butylcalix[8]arene (5). The increase in solubility of drugs by the calixarene host 1 to 5 was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug-cyclodextrin complexes.en_US
dc.description.sponsorshipS.U. Research FoundationSelcuk University [BAP: 10101016]; Research Laboratory of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThe authors gratefully would like to thank S.U. Research Foundation (BAP: 10101016) for financial support.; The authors gratefully acknowledge support of this study produced from a part of the Ph.D. Thesis of Mevlut Bayrakci by the Research Laboratory of Selcuk University.en_US
dc.identifier.citationBayrakçı, M., Ertul, Ş., Yılmaz, M., (2012). Phase Solubility Studies of Poorly Soluble Drug Molecules by Using O-Phosphorylated Calixarenes as Drug-Solubilizing Agents. Journal of Chemical and Engineering Data, 57, 233-239. Doi: 10.1021/je200992c
dc.identifier.doi10.1021/je200992cen_US
dc.identifier.endpage239en_US
dc.identifier.issn0021-9568en_US
dc.identifier.issn1520-5134en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://dx.doi.org/10.1021/je200992c
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28299
dc.identifier.volume57en_US
dc.identifier.wosWOS:000298978900036en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorErtul, Şeref
dc.institutionauthorErtul, Şeref
dc.institutionauthorYılmaz, Mustafa
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.relation.ispartofJournal of Chemical and Engineering Dataen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titlePhase Solubility Studies of Poorly Soluble Drug Molecules by Using O-Phosphorylated Calixarenes as Drug-Solubilizing Agentsen_US
dc.typeArticleen_US

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