Köpeklerde deneysel akut pankreatitiste klinik-patolojik ve patolojik incelemeler
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Tarih
1997
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info:eu-repo/semantics/openAccess
Özet
Bu çalışma, köpeklerde oleik asit verilerek akut pankreatitis oluşturmak ve hastalığın klinik-patolojik ve patolojik özelliklerini incelemek amacıyla yapıldı. Bunun için 7'si deneme grubu, 6'sı kontrol grubu olmak üzere toplam 13 adet sağlıklı köpek kullanıldı. Deneme grubu köpeklerde laparatomi ile açığa çıkarılan pankreasın loblarına oleik asit (0.5 ml/kg) enjekte edildi. Deneme grubu köpeklerde klinik olarak ateş, anoreksi, depresyon, kusma ve yağlı diyare görüldü. Klinik-patolojik incelemelerde ortalama serum kolesterol ve serum trigliserid konsantrasyonları, serum amilaz ve lipaz aktiviteleri ile idrar amilaz / kreatinin oranında artış görüldü. Ortalama serum ALP aktivitesinde artış vardı, ancak serum ALT aktivitesinde önemli bir farklılık gözlenmedi. Patolojik incelemelerde deneme grubu köpeklerde hemorajik nekrotik pankreatitis, yağ nekrozu, damarlarda tromboz ve bazı olgularda apseleşmeler tespit edildi. Sonuç olarak oleik asit ile oluşturulan akut pankreatitisin teşhisinde serum lipaz aktivitesiyle birlikte idrar amilaz /kreatinin oranının belirlenmesinin faydalı olabileceği kanısına varıldı.
The aim of this study was to investigate the clinicopathologic and pathologic features of experimentally induced acute pancreatitis in dogs. Total 13 healthy dogs were used and grouped as experimental group (7 dogs) and control group (6 dogs). After laparatomie, oleic acid (0.5 ml/kg body weight) was injected into pancreas of experimental group dogs. Clinically, the experimental group dogs were showed fever, anorexia, depression, vomiting and steatorrhea. The median serum cholesterole and trigliseride concentrations, median serum amylase and lipase activities, and urine amylase/creatinine ratio were increased in the experimental group when compared with the values of control group dogs. The median serum ALP activities were increased, whereas the median serum ALT activities did not show any significant alteration. Pathologically, haemorrhagic-necrotic pancreatitis, thrombosis of blood vessels, fat necrosis and in some cases abscessation were detected in the pancreas of experimental group dogs. In conclusion, the combination of serum lipase enzyme activity with urine amylase/creatinine ratio, might be useful in the diagnosis of acute pancreatitis.
The aim of this study was to investigate the clinicopathologic and pathologic features of experimentally induced acute pancreatitis in dogs. Total 13 healthy dogs were used and grouped as experimental group (7 dogs) and control group (6 dogs). After laparatomie, oleic acid (0.5 ml/kg body weight) was injected into pancreas of experimental group dogs. Clinically, the experimental group dogs were showed fever, anorexia, depression, vomiting and steatorrhea. The median serum cholesterole and trigliseride concentrations, median serum amylase and lipase activities, and urine amylase/creatinine ratio were increased in the experimental group when compared with the values of control group dogs. The median serum ALP activities were increased, whereas the median serum ALT activities did not show any significant alteration. Pathologically, haemorrhagic-necrotic pancreatitis, thrombosis of blood vessels, fat necrosis and in some cases abscessation were detected in the pancreas of experimental group dogs. In conclusion, the combination of serum lipase enzyme activity with urine amylase/creatinine ratio, might be useful in the diagnosis of acute pancreatitis.
Açıklama
Anahtar Kelimeler
Veterinerlik
Kaynak
Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
2
Künye
Kıran, M. M., Çankaya, H., Hatipoğlu, F. (1997). Köpeklerde Deneysel Akut Pankreatitiste Klinik-Patolojik ve Patolojik İncelemeler. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, 13(2), 149-157.
