The effects of adding diphenhydramine hydrochloride to lidocaine in intravenous regional anaesthesia

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dc.contributor.authorReisli, R
dc.contributor.authorCelik, J
dc.contributor.authorTuncer, S
dc.contributor.authorApilliogullari, S
dc.contributor.authorDuman, A
dc.contributor.authorYosunkaya, A
dc.contributor.authorOkesli, S
dc.date.accessioned2020-03-26T16:46:11Z
dc.date.available2020-03-26T16:46:11Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aimed to evaluate whether diphenhydramine hydrochloride (DPH) could be used to reduce the dose of lidocaine for intravenous regional anaesthesia (IVRA). Sixty patients undergoing upper limb operations were divided into three groups (20 each). All patients received IVRA as follows: group 1 received 3 mg/kg lidocaine, group 2 received 40 mg DPH and 1.5 mg/kg lidocaine, and group 3 received 1.5 mg/kg lidocaine diluted to 40 ml with 0.9% saline solution. The onset of sensory block was tested by a pinprick. The duration of anaesthesia time was also recorded. Intraoperative pain was assessed using a five point pain score system. Side effects during surgery and after release of the tourniquet were recorded. Only 4 patients in group 3 had sufficient analgesia. Therefore, the patients in group 3 were excluded from the study. Data from 40 patients (group I and 2) were analysed. The onset time of sensory block was significantly shorter in group I than group 2 (2.4 +/- 1.54 min and 6.85 +/- 1.46 min, respectively). The tourniquet pain time was also significantly longer in group I than in group 2 (57.15 +/- 10.90 min and 42.65 +/- 9.67 min, respectively). One patient from each group experienced tinnitus for 30-60 s, and 4 patients in group 2 had minimal sedation after tourniquet release. According to our results, DPH is a safe and useful adjunct to IVRA in minor procedures of short duration. Decreasing the dose of lidocaine also decreases the risk of local anaesthetic toxicity in the event of accidental release of tourniquet pressure.en_US
dc.identifier.doi10.1163/156856903770196836en_US
dc.identifier.endpage446en_US
dc.identifier.issn0169-1112en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://dx.doi.org/10.1163/156856903770196836
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18591
dc.identifier.volume15en_US
dc.identifier.wosWOS:000187039500015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVSP BVen_US
dc.relation.ispartofPAIN CLINICen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectintravenous regional anaesthesiaen_US
dc.subjectlidocaineen_US
dc.subjectdiphenhydramineen_US
dc.titleThe effects of adding diphenhydramine hydrochloride to lidocaine in intravenous regional anaesthesiaen_US
dc.typeArticleen_US

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