Alcoholic extract of tarantula cubensis induces apoptosis in MCF-7 cell line

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dc.contributor.authorAyse E.R.
dc.contributor.authorCorum O.
dc.contributor.authorCorum D.
dc.contributor.authorHitit M.
dc.contributor.authorDonmez H.
dc.contributor.authorGuzeloglu A.
dc.date.accessioned2020-03-26T19:43:42Z
dc.date.available2020-03-26T19:43:42Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTarantula cubensis Alcoholic Extract (TCAE) is a homeopathic agent used for treating many disorders. This study aimed to define the effects of TCAE on the breast carcinoma cell line (MCF-7). After various concentrations (10, 20, 40, 80 and 160 µl/ml) of TCAE were applied to MCF-7 cells and the human embryonic kidney cell line (HEK293), the cells were incubated for 1, 3, 6, 9, 12, 24 and 48 h, followed by analysis by MTT assays. According to the results of the MTT assays, cells treated with 20 or 40 µl/ml TCAE for 6 h were applied to apoptosis analysis by flow cytometry. Secreted levels of tumor necrosis factor alpha (TNF?), interleukin (IL)-1?, IL-6, IL-10, Interferon-? (IFN?), Transforming Growth Factor-? (TGF?), and Nuclear Factor-kappa B (NF-?B) were measured using ELISAs. TNF? and TGF? levels increased while IL-6 and IL-10 levels fluctuated in MCF-7 cells. In conclusion, our study suggests that TCAE may change the normal cancer physiology and lead to cell death by activating apoptosis in MCF-7 cells. © 2017, Scientific Publishers of India. All rights reserved.en_US
dc.identifier.endpage3665en_US
dc.identifier.issn0970938Xen_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3660en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35736
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers of Indiaen_US
dc.relation.ispartofBiomedical Research (India)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectApoptosisen_US
dc.subjectCytokinesen_US
dc.subjectMCF-7en_US
dc.subjectTarantula cubensis alcoholic extracten_US
dc.subjectTheranekronen_US
dc.titleAlcoholic extract of tarantula cubensis induces apoptosis in MCF-7 cell lineen_US
dc.typeArticleen_US

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