Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke

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dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorÖztürk, Şerefnur
dc.contributor.authorEkmekci, Hakan
dc.contributor.authorSağlam, Aslıhan
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorÜnlü, Ali
dc.date.accessioned2020-03-26T19:53:44Z
dc.date.available2020-03-26T19:53:44Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: Sitosterolemia, defined as phytosterolemia, is a rare autosomal recessive disease characterized by elevated blood sterol levels. Our aim was to investigate serum plant sterols, methylmalonic acid, vitamin B12, oxidized-LDL and homocysteine levels in ischemic and hemorrhagic stroke patients and healthy subjects. Material and Methods: 50 healthy subjects (without a family history of coronary artery disease) and 89 patients hospitalized in the Selcuk University neurology clinic or intensive care unit with a diagnosis of stroke were included in this study. Serum plant sterols, homocysteine and methylmalonic acid, oxidized-LDL, total cholesterol, triglycerides, HDL-Cholesterol and vitamin B12 levels were analyzed by gas chromatography-mass spectrometry, liquid-chromatography tandem mass spectrometry, commercially available ELISA kit, spectrophotometry and chemiluminescence methods, respectively. Results: Urinary methylmalonic acid/creatinine ratio (p< 0.05), serum beta-sitosterol levels and beta-sitosterol/cholesterol ratio were significantly higher (p < 0.01) in patients compared to the control group. There was a significant positive correlation between the serum OxLDL-methylmalonic acid, serum homocysteine-urinary methylmalonic acid/creatinine ratio, serum methylmalonic acid-Urinary methylmalonic acid (p< 0.05), serum homocysteine-urinary methylmalonic acid, urinary methylmalonic acid-methylmalonic acid/creatinine ratio, serum methylmalonic acid-methylmalonic acid/creatinine ratio, serum beta-sitosterol-beta-sitosterol/cholesterol, total cholesterol-HDL, total cholesterol-LDL (p < 0.01) levels and negative correlation between vitamin B12-serum methylmalonic acid (p< 0.05), cholesterol-stigmasterol/cholesterol, LDL-stigmasterol/cholesterol (p < 0.01) levels in the patient group. Conclusion: Our findings presented that the serum sitosterol levels were significantly higher in stroke patients compared to controls.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects Department (BAP), Konya, Turkey [13401130]en_US
dc.description.sponsorshipThis research was supported by Selcuk University, Scientific Research Projects Department (BAP), (Project number, 13401130), Konya, Turkey.en_US
dc.identifier.doi10.2478/rrlm-2018-0003en_US
dc.identifier.endpage58en_US
dc.identifier.issn1841-6624en_US
dc.identifier.issn2284-5623en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://dx.doi.org/10.2478/rrlm-2018-0003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36580
dc.identifier.volume26en_US
dc.identifier.wosWOS:000423997300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUNIV PRESSen_US
dc.relation.ispartofREVISTA ROMANA DE MEDICINA DE LABORATORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsterolen_US
dc.subjectstrokeen_US
dc.subjectoxidized LDLen_US
dc.subjectmethylmalonic aciden_US
dc.subjectcreatinineen_US
dc.titleElevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Strokeen_US
dc.typeArticleen_US

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