A comparative study of the chemical composition, biological and multivariate analysis of Crotalaria retusa L. stem barks, fruits, and flowers obtained via different extraction protocols

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dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorSaftic, Lara
dc.contributor.authorPersuric, Zeljka
dc.contributor.authorPavelic, Sandra Kraljevic
dc.contributor.authorEtienne, Ouattara Katinan
dc.contributor.authorPicot-Allain, Marie Carene Nancy
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:20:04Z
dc.date.available2020-03-26T20:20:04Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractCrotalaria retusa L (Fabaceae) also known as 'rattlebox' has been used in traditional medicine for the management of various human ailments. The present study comparatively evaluated the alpha-amylase, alpha-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory activity, antioxidant properties, as well as phytochemical profiles of extracts of C. retusa (bark, fruits, and flowers) obtained by homogenization, maceration, ultrasonication, and Soxhlet extractions. Little variation was noted between the phytochemical profiles obtained by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) of C. retusa same plant parts extracted by different methods while the different plant parts showed specific phytochemical fingerprints. For instance, myricetin was identified in C. retusa fruits only. Fruit and bark extracts possessed the highest concentrations of quercetin and rutin, respectively. p-hydroxybenzoic acid, a phenolic derivative of benzoic acid, was identified in all C. retusa plant parts. Spectrophotometric determinations revealed that C. retusa bark extracts have highest concentrations of phenolic and flavonoids. Besides, C. retusa bark extracts showed highest antioxidant capacity. The extracts showed high inhibitory activity against alpha-glucosidase (21.22-4.81 mmol acarbose equivalent/g), acetylcholinesterase (8.71-8.26 mg galantamine equivalent/g), butyrylcholinesterase (4.16-2.36 mg galantamine equivalent/g), and tyrosinase (133.11-125.26 mg kojic acid equivalent/g). Multivariate component analysis showed that the plant part was the main factor responsible for the observed variability between the extracts. Data collected proved that C. retusa has the potential for the development of novel biopharmaceutical, nutraceutical, and cosmetical products. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipEuropean Regional Development Fund (ERDF)European Union (EU); University of Rijeka [uniri-biomed-18-133]; Croatian Government; European Union (European Regional Development Fund-the Competitiveness and Cohesion Operational Programme) [KK.01.1.1.01, KK.01.1.1.01.0002]en_US
dc.description.sponsorshipWe greatly appreciate the granted access to equipment owned by the University of Rijeka within the project "Research Infrastructure for Campus-based Laboratories at University of Rijeka," financed by the European Regional Development Fund (ERDF). We also acknowledge the University of Rijeka research support uniri-biomed-18-133. We would like to thank Croatian Government and the European Union (European Regional Development Fund-the Competitiveness and Cohesion Operational Programme - KK.01.1.1.01) for funding this research through project Bioprospecting of the Adriatic Sea (KK.01.1.1.01.0002) granted to The Scientific Centre of Excellence for Marine Bioprospecting-BioProCro.en_US
dc.identifier.citationSinan, K. I., Saftic, L., Persuric, Z., Pavelic, S. K., Etienne, O. K., Picot-Allain, M. C. N., Mahomoodally, M. F., Zengin, G. (2020). A Comparative Study of the Chemical Composition, Biological and Multivariate Analysis of Crotalaria retusa L. stem barks, Fruits, and Flowers Obtained via Different Extraction Protocols. South African Journal of Botany, 128, 101-108.
dc.identifier.doi10.1016/j.sajb.2019.10.019en_US
dc.identifier.endpage108en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2019.10.019
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38495
dc.identifier.volume128en_US
dc.identifier.wosWOS:000506413200012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSinan, Kouadio Ibrahime
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSOUTH AFRICAN JOURNAL OF BOTANYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRattleboxen_US
dc.subjectEnzymeen_US
dc.subjectExtraction techniquesen_US
dc.subjectAntioxidanten_US
dc.subjectMass spectrometryen_US
dc.titleA comparative study of the chemical composition, biological and multivariate analysis of Crotalaria retusa L. stem barks, fruits, and flowers obtained via different extraction protocolsen_US
dc.typeArticleen_US

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