Impairment of Glucose Tolerance Test During Pregnancy and Serum Assymmetric Dimethylarginine Levels

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dc.contributor.authorFındık, Rahime Bedir
dc.contributor.authorÇelik, Hüseyin Tuğrul
dc.contributor.authorYılmaz, Fatma Meriç
dc.contributor.authorYılmaz, Ömer Hınç
dc.contributor.authorAbuşoğlu, Sedat
dc.date.accessioned2020-03-26T19:24:39Z
dc.date.available2020-03-26T19:24:39Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: Assymetric dimethylarginin (ADMA), an inhibitor of nitric oxide synthase (NOS), has been linked to endothelial dysfunction. Our aim in this study was to compare ADMA and arginine levels in normal glucose tolerance, impaired glucose tolerance and gestational diabetes groups and investigate the effect on baby birth weight. Material and Method: Serum ADMA and arginine levels were investigated in 64 patients whose 50-g glucose loading test was normal (group 1, NGT); 33 patients whose 50-g test result was high and those whose 100-g oral glucose tolerance test (OGTT) was normal, namely, those with impaired glucose tolerance (IGT, group 2); and in 8 patients diagnosed with gestational diabetes mellitus (GDM, group 3). Results: Arginine levels were significantly higher in the IGT group than in the NGT group. ADMA levels were high in the GDM group, but the difference was not statistically significant. There were a statistically significant correlation between arginine and ADMA levels and the ADMA level of those with a diabetes history. No significant relationship was found between ADMA level, arginine and the weight of the infant. Discussions: Although there has not been a clinical status related with nitric oxide deficiency caused by increasing ADMA concentrations, pregnancies with increased body mass indeks (BMI), family history for diabetes and older ages should be carefully monitorized. ADMA tends to increase in patients with IGT and GDM. In addition, blood ADMA and arginine levels do not seem to influence the weight of the infant.en_US
dc.identifier.doi10.4328/JCAM.2657en_US
dc.identifier.endpage303en_US
dc.identifier.issn1309-0720en_US
dc.identifier.issn1309-2014en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage300en_US
dc.identifier.urihttps://dx.doi.org/10.4328/JCAM.2657
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33697
dc.identifier.volume7en_US
dc.identifier.wosWOS:000376566800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDERMAN MEDICAL PUBLen_US
dc.relation.ispartofJOURNAL OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectGestational Diabetesen_US
dc.subjectImpaired Glucose Toleranceen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectArginineen_US
dc.titleImpairment of Glucose Tolerance Test During Pregnancy and Serum Assymmetric Dimethylarginine Levelsen_US
dc.typeArticleen_US

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