The effects of sufentanil and remifentanil in the isolated perfused rat kidney [Sufentanil ve remifentanilin izole perfüze rat böbre?i üzerine etkileri]

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dc.contributor.authorTuncer S.
dc.contributor.authorBarişkaner H.
dc.contributor.authorYosunkaya A.
dc.contributor.authorKiliç M.
dc.contributor.authorDo?an N.
dc.contributor.authorOtelcio?lu Ş.
dc.date.accessioned2020-03-26T16:55:42Z
dc.date.available2020-03-26T16:55:42Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, the effects of indomethacin (prostaglandin synthase inhibitor), propranolol (beta adrenergic receptors blocker), tetraethylammonium (TEA) (calcium-dependent potassium channel blocker) and glibenclamide (ATP-sensitive potassium channel blocker), NG nitro-L-arginine (NO synthetase inhibitor) and naloxame (nonselective opioid receptor antagonists) on the responses induced by sufentanil and remifentanil were investigated in the isolated perfused rat kidney. Renal arter was cannulated. Then the kidney was perfused continueously with warmed (37 °C) and aerated (95% O 2 and 5% CO 2). Krebs Henselieit solution by using a peristaltic pump delivering a constat flow (8-10 ml/min). Vascular responses were detected as changes in perfussion pressure, which was monitored continuously with a pressure transuder and recorded on polygraph. After phenilephrine (PE)-induced vasoconstriction had reached a platoe, sufentanil or remifentanil were given. Vasodilatation was recorded. Antagonists or inhibitors were added and responses were recorded. At the end of each experiment; papaverine was used to obtain the maximum dilatation. None of the used antagonists or inhibitors were not effected the submaximum PE construction. The used opioids were not alter in basal perfusion pressure. Antagonists or inhibitors had no effect on papaverine-induced dilatation. Bolus addition of sufentanil and remifentanil produced concentration dependent vasodilation. Indomethacine L-NAME, propranolol, naloxone and glibenclamide did not significantly alter responses of both of the opioids (p>0.05). But, sufentanil and remifentanil induced dilatation were significantly affected by TEA (p<0.05). The present results demonstrated that sufentanil and remifentanil decrease perfusion pressure in the isolated rat kidney and such mechanism may involve the calcium actived K + channels activation.en_US
dc.identifier.endpage61en_US
dc.identifier.issn1300-0012en_US
dc.identifier.issue2en_US
dc.identifier.pmid15152536en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19307
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofAgrien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIsolated-perfused kidneyen_US
dc.subjectRaten_US
dc.subjectRemifentanilen_US
dc.subjectSufentanilen_US
dc.titleThe effects of sufentanil and remifentanil in the isolated perfused rat kidney [Sufentanil ve remifentanilin izole perfüze rat böbre?i üzerine etkileri]en_US
dc.typeArticleen_US

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