Effect of flunixin meglumin on the antioxidant status in endotoxemia

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dc.contributor.authorKonyalioglu, S.
dc.contributor.authorEr, A.
dc.contributor.authorUney, K.
dc.contributor.authorElmas, M.
dc.contributor.authorYazar, E.
dc.date.accessioned2020-03-26T17:17:16Z
dc.date.available2020-03-26T17:17:16Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, the effects of flunixin meglumin on the antioxidant status during endotoxemia were investigated. Thirty Balb/C mice were divided into three equal groups. Mice with no treatment formed the control group (group I). Mice treated with lipopolysaccharide (LPS) and LPS + flunixin meglumin (FM) formed groups II and III, respectively. An mice were sacrificed and tissue samples were collected 6 hours after treatments. Activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), as well as levels of malondialdehyde (MDA) and glutathione (GSH) were determined spectrophotometrically. LPS caused a significant (p < 0.05) increase in levels of MDA (heart, kidney, spleen) which is an accepted biomarker of oxidative stress, and changed the levels of SOD, GPX, CAT and GSH. When FM was administered simultaneously with LPS, FM inhibited (p < 0.05) the increase of MDA levels in an tissues. As results, LPS caused MDA levels and oxidative stress to increase. However, FM depressed the LPS induced increase of MDA levels. This antioxidant effect of FM may be beneficial in endotoxemia.en_US
dc.identifier.doi10.2298/AVB0703241Ken_US
dc.identifier.endpage246en_US
dc.identifier.issn0567-8315en_US
dc.identifier.issn1820-7448en_US
dc.identifier.issue02.03.2020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://dx.doi.org/10.2298/AVB0703241K
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21337
dc.identifier.volume57en_US
dc.identifier.wosWOS:000247445700015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSCIENDOen_US
dc.relation.ispartofACTA VETERINARIA-BEOGRADen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectflunixin megluminen_US
dc.subjectantioxidant statusen_US
dc.subjectendotoxemiaen_US
dc.titleEffect of flunixin meglumin on the antioxidant status in endotoxemiaen_US
dc.typeArticleen_US

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