The Importance of Cystatin-C for Predicting Nephrotoxicity in Children with Acute Leukemia and Non-Hodgkin Lymphoma

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dc.contributor.authorUnal, Ekrem
dc.contributor.authorCaliskan, Uemran
dc.contributor.authorKoksal, Yavuz
dc.date.accessioned2020-03-26T17:40:44Z
dc.date.available2020-03-26T17:40:44Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDetermination of renal function in patients with childhood cancer by a simple and accurate test is crucial. The aim of this study is to determine the incidence of nephrotoxicity in patients with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and non-Hodgkin lymphoma (NHL) and evaluate the importance of serum cystatin-C for an early predictor of impairment of renal function. 27 patients (ages varied from 1.5 to 16 years, median age 10 year-old) were enrolled to this study. Serum urea, creatinine, cystatin-C concentrations and calculated creatinine clearances of the patients were determined during the treatment. Twenty (74%) of patients were male and seven (26%) were female. The frequencies of the diagnosis for ALL, AML and NHL were 13 (48.1%), 8 (29.6%) and 6 (22.3%), respectively. The mean values of cystatin C during the treatment were 0.77 +/- 0.3 mg/l, 0.86 +/- 0.5 mg/l and 0.81 +/- 0.3 mg/l, respectively. The values of urea, cystatin-C, and creatinine clearance did not differ statistically by duration of the treatment. We did not observe any renal impairment in our study group by the treatment. Cystatin-C has high values of sensitivity and specificity to predict the glomeruler filtration rate. Therefore cystatin C might be useful for determination glomeruler filtration rate in children with cancer; especially who have difficulties in collecting 24-hours urine sample.en_US
dc.identifier.endpage74en_US
dc.identifier.issn1306-133Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23952
dc.identifier.volume19en_US
dc.identifier.wosWOS:000271595500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChildhood cancersen_US
dc.subjectChemotherapyen_US
dc.subjectNephrotoxicityen_US
dc.subjectCystatin-Cen_US
dc.titleThe Importance of Cystatin-C for Predicting Nephrotoxicity in Children with Acute Leukemia and Non-Hodgkin Lymphomaen_US
dc.typeArticleen_US

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