Cooling and Response to Histamine in Calf Cardiac Vein

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dc.contributor.authorAtalik, K. E.
dc.contributor.authorKılıç, M.
dc.date.accessioned2020-03-26T17:45:48Z
dc.date.available2020-03-26T17:45:48Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present work we studied the responses of calf cardiac vein to histamine (10-9-3x10-4M) and effects of moderate cooling (to 28 °C) on these responses with analysis of the role of endothelial mediators and K+ -ions. Concentration-response curves to histamine were isometrically recorded at 37 and 28 °C (control). The same procedure was repeated at 28°C in the presence of NG-nitro-L-arginine methyl ester (L-NAME, 10-4 M), indomethacin (10-5 M), and also in the K+-free medium. During cooling, the sensitivity, but not the maximal response, was significantly lower than 37 °C. Cooling to 28°C after treatment with L-NAME did not modify the effect of cooling, whereas treatment with indomethacin increased, significantly. Furthermore, cooling to 28 C after incubation in K+-free solution increased the sensitivity to histamine. The results of this study suggest the role of cyclooxygenase pathway and also K+ ions in the cooling-induced changes of calf cardiac vein treated with histamine.en_US
dc.identifier.citationAtalik, K. E., Kılıç, M., (2009). Cooling and Response to Histamine in Calf Cardiac Vein. Journal of Applied Biological Sciences, 3(3), 33-37.
dc.identifier.endpage37en_US
dc.identifier.issn1307-1130en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24123
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAtalik, K. E.
dc.institutionauthorKılıç, M.
dc.language.isoenen_US
dc.relation.ispartofJournal of Applied Biological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCardiac veinen_US
dc.subjectCoolingen_US
dc.subjectHistamineen_US
dc.subjectK+ ionen_US
dc.subjectNitric oxideen_US
dc.titleCooling and Response to Histamine in Calf Cardiac Veinen_US
dc.typeArticleen_US

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