Enantioselective hydrolysis of (R/S)-Naproxen methyl ester with sol-gel encapculated lipase in presence of calix[n]arene derivatives

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dc.contributor.authorSahin, Ozlem
dc.contributor.authorErdemir, Serkan
dc.contributor.authorUyanik, Arzu
dc.contributor.authorYilmaz, Mustafa
dc.date.accessioned2020-03-26T17:38:33Z
dc.date.available2020-03-26T17:38:33Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLipases are enzymes that catalyses a variety of reactions, such esterifications, interesterification and hydrolysis. Several methods have been reported for the immobilization of lipases, such as deposition onto solid supports, covalent binding and encapsulation within a polymer matrix or silica glasses obtained by sol-gel techniques. In this study, the Candido rugosa lipase was encapsulated within a chemically inert sol-gel support prepared by polycondensation by tetraetoxysilane (TEOS)and octyltrietoxysilane(OTES) in the presence and absence of calix[n]arene, calix[n]-NH2 and calix[n]-COOH (n = 4,6,8) compounds as additives. The catalytic activity of the encapsulated lipases was evaluated into model reactions, i.e. the hydrolysis of p-nitrophenylpalmitate (p-NPP), and the enantioselective hydrolysis of rasemic Naproxen methyl ester that was studied in aqueous buffer solution/isooctane reaction system. The results indicated that the particularly calix[4,6]-NH2 and calix[6]-COOH based encapsulated lipases had higher conversion and enantioselectivity compared to the sol-gel free lipase. (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk University; Scientific and Technical Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106T435]en_US
dc.description.sponsorshipWe would like to thank The Research Foundation of Selcuk University (BAP) and The Scientific and Technical Research Council of Turkey (TUBITAK-Grant Number 106T435) for financial support of this work.en_US
dc.identifier.doi10.1016/j.apcata.2009.08.030en_US
dc.identifier.endpage41en_US
dc.identifier.issn0926-860Xen_US
dc.identifier.issn1873-3875en_US
dc.identifier.issue01.02.2020en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.apcata.2009.08.030
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23511
dc.identifier.volume369en_US
dc.identifier.wosWOS:000271689600005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofAPPLIED CATALYSIS A-GENERALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalixarenesen_US
dc.subjectEnzymeen_US
dc.subjectEncapsulationen_US
dc.subjectEnantioselectivityen_US
dc.subjectSol-gelen_US
dc.titleEnantioselective hydrolysis of (R/S)-Naproxen methyl ester with sol-gel encapculated lipase in presence of calix[n]arene derivativesen_US
dc.typeArticleen_US

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