The effects of melatonin on oxidative stress markers in an animal model of radiocontrast-induced nephropathy

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dc.contributor.authorBayir, Aysegul
dc.contributor.authorKara, Hasan
dc.contributor.authorKiyici, Aysel
dc.contributor.authorKiyici, Halil
dc.contributor.authorAk, Ahmet
dc.date.accessioned2020-03-26T18:16:52Z
dc.date.available2020-03-26T18:16:52Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated the effects of melatonin on erythrocyte and renal tissue superoxide dismutase (SOD) and malondialdehyde (MDA) levels in rabbits after the administration of a radiocontrast agent. Twenty-four New Zealand rabbits were divided into four groups, six rabbits in each: control, sham, hydration, and hydration plus melatonin. Rabbits in the control group were sacrificed after the extraction of renal tissue. All other rabbits received a single dose of IV diatrizoat sodium (10 mL/kg). In the hydration group, saline (10 mL/kg IV) was infused at 6 hour intervals. In the hydration plus melatonin group, melatonin (10 mg/kg IV) and saline (10 ml/kg IV) were administered at 6 hour intervals. Venous blood samples were obtained from the rabbits before, and 48 and 72 hours after diatrizoat sodium administration to measure serum urea, creatinine, sodium, potassium, calcium, and erythrocyte MDA levels and SOD activities. Renal tissues were removed at the end of 72 hours, and tissue MDA levels and SOD activities were determined. At 72 hours, erythrocyte MDA concentrations of the hydration plus melatonin animals were significantly lower than those of the sham and hydration groups. However, erythrocyte and renal tissue SOD activities were significantly higher in the hydration plus melatonin group than the other groups. Renal tissue MDA levels of the hydration plus melatonin group were significantly lower than those of the sham and hydration groups. Melatonin has favorable effects on lipid peroxidation and antioxidant status in this animal model of radiocontrast nephropathy.en_US
dc.identifier.endpageU210en_US
dc.identifier.issn0970-938Xen_US
dc.identifier.issn0976-1683en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26941
dc.identifier.volume22en_US
dc.identifier.wosWOS:000208597300011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherALLIED ACADen_US
dc.relation.ispartofBIOMEDICAL RESEARCH-INDIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectradiocontrast-induced nephropathyen_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectmalondialdehydeen_US
dc.titleThe effects of melatonin on oxidative stress markers in an animal model of radiocontrast-induced nephropathyen_US
dc.typeArticleen_US

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