Qualitative fingerprint analysis and multidirectional assessment of different crude extracts and essential oil from wild Artemisia santonicum L.

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dc.authorid0000-0001-9431-9407
dc.authorid0000-0001-6548-7823
dc.authorid0000-0002-7346-7395
dc.authorid0000-0003-2090-1634
dc.authorid0000-0002-1846-3236
dc.authorid0000-0002-6398-0371
dc.authorid0000-0003-3962-8666
dc.contributor.authorFerrante, Claudio
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMenghini, Luigi
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Sheila
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorLobine, Devina
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorOrlando, Giustino
dc.date.accessioned2020-03-26T20:19:12Z
dc.date.available2020-03-26T20:19:12Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractArtemisia species are used as folk medicines in several countries. This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase alpha-amylase, and alpha-glucosidase) as well of their antioxidant and pharmacological effects. The chemical profile of the essential oil was determined using gas chromatography coupled to mass spectrometry (GC-MS) analysis, while the extracts were chemically characterized by high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Forty-nine constituents were identified and camphor (36.6%), 1,8-cineole (10.2%), alpha-thujone (10.1%), borneol (4.5%), and beta-thujone (3.6%) were the major components. Overall, 45, 74, and 67 components were identified from the ethyl acetate, methanol, and water extracts, respectively. The EO and extracts showed significant antioxidant properties, in a cell-free model; particularly, methanol and water extracts revealed promising sources of antioxidant compounds. Additionally, we evaluated protective effects of EO and extracts in isolated rat colon tissue challenged with lipopolysaccharide (LPS), as an ex vivo model of colon inflammation, and human colon cancer HCT116 cell line. Particularly, we observed that, among all tested samples, A. santonicum ethyl acetate displayed the best pharmacological profile, being able to blunt LPS-induced levels of all tested biomarkers of inflammation and oxidative stress, including colon nitrites, lactate dehydrogenase, prostaglandin E-2, and serotonin. Additionally, this extract was also able to reduce HCT116 cell viability, thus suggesting potential antiproliferative effects against colon cancer cells. Based on our results, A. santonicum has great potential for developing novel functional agents including pharmaceuticals, cosmeceuticals, and nutraceuticals.en_US
dc.description.sponsorshipItalian Ministry of UniversityMinistero dell' Istruzione, dell' Universita e della Ricerca (MIUR)en_US
dc.description.sponsorshipThis work was supported by grants from the Italian Ministry of University (FAR 2016 granted to Claudio Ferrante; FAR 2018 granted to Giustino Orlando; FAR 2016 granted to Luigi Menghini). Animal experimental procedures were approved by Italian Ministry of Health (authorization no. F4738. N. XTQ, delivered on 11 November 2018).en_US
dc.identifier.citationFerrante, C., Zengin, G., Menghini, L., Diuzheva, A., Jeko, J., Cziaky, Z., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Lobine, D., Şenkardeş, İ., Mahomoodally, M. F., Orlando, G. (2019). Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L. Processes, 7(8), 522.
dc.identifier.doi10.3390/pr7080522en_US
dc.identifier.issn2227-9717en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.3390/pr7080522
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38141
dc.identifier.volume7en_US
dc.identifier.wosWOS:000483747700071en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPROCESSESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectArtemisiaen_US
dc.subjectEssential oilen_US
dc.subjectBioactive compoundsen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.titleQualitative fingerprint analysis and multidirectional assessment of different crude extracts and essential oil from wild Artemisia santonicum L.en_US
dc.typeArticleen_US

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