Effects of Cooling on Contractions of Calf Coronary Artery: Role of the Endothelium
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effects of cooling on vasoconstrictions induced by contractile agents and role of the endothelium in this effect were analyzed in calf coronary artery. Potassium chloride (KCl, 10-3 - 5 × 102 M), 5-hydroxytryptamine (5-HT, 10-9 - 3 × 10-4 M) and carbachol (10-9 - 3 × 10-4 M) induced concentration-dependent contractions at both 37°C and 28°C (cooling). During cooling the sensitivities, but not the maximal responses to KCl, 5-HT and carbachol were significantly lower than at 37°C. Endothelium removal or NG-nitro-L arginine methyl esther (LNAME, 10-5 M) pretreatment did not modify the effect of cooling. These results suggest that cooling-induced responses in calf coronary artery are independent of endothelium (nitric oxide).
Açıklama
Anahtar Kelimeler
Contractions, Cooling, Coronary artery (calf), Nitric oxide
Kaynak
Asia Pacific Journal of Pharmacology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
15
Sayı
3
Künye
Atalık, K. E., Şahin, A. S., Doğan, N., (2001). Effects of Cooling on Contractions of Calf Coronary Artery: Role of the Endothelium. Asia Pacific Journal of Pharmacology, 15(3), 33-36.
