Chemical Composition of Essential Oil, Antioxidant, Antidiabetic, Anti-obesity, and Neuroprotective Properties of Prangos gaubae

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dc.contributor.authorBahadori, Mir Babak
dc.contributor.authorZengin, Gökhan
dc.contributor.authorBahadori, Shahram
dc.contributor.authorMaggi, Filippo
dc.contributor.authorDinparast, Leila
dc.date.accessioned2020-03-26T19:34:17Z
dc.date.available2020-03-26T19:34:17Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractChemical composition of essential oil and the potential of Prangos gaubae for the management of public health problems such as Alzheimer's disease, obesity, Diabetes mellitus, and skin diseases were evaluated for the first time. In this direction, enzyme inhibitory effects, antioxidant activity, and total bioactive contents of the plant were determined. EO showed high acetylcholinesterase (2.97 mg GEs/g oil), alpha-amylase (1.35 mmol ACEs/g oil), alpha-glucosidase (38.84 mmol ACEs/g oil), and lipase (1.59 mmol OEs/g oil) inhibitory activities. Moreover, strong antioxidant effects were observed in antiradical (DPPH and ABTS), reducing power (CUPRAC and FRAP), total antioxidant, and metal chelating assays. Methanol extract exhibited promising DPPH radical scavenging activity (0.47 mmol TEs/g extract) and also high reducing power in CUPRAC (0.89 mmol TEs/g extract) and FRAP (0.52 mmol TEs/g extract) assays. All extracts showed low total flavonoid but high total phenolics content. Furthermore, they exhibited strong skin-care effect in tyrosinase inhibition assay. EO analysis showed the presence of germacrene D (26.7%), caryophyllene oxide (14.3%), (E)-caryophyllene (13.8%), and spathulenol (11.3%) as the major volatile components. Results indicated that P. gaubae has promising potential for possible uses in food, cosmetic, and pharmaceutical industries due to its valuable phytoconstituents and biological activities.en_US
dc.description.sponsorshipUrmia branch of the Islamic Azad Universityen_US
dc.description.sponsorshipThis work was supported by the Urmia branch of the Islamic Azad University.en_US
dc.identifier.endpage1948en_US
dc.identifier.issn1934-578Xen_US
dc.identifier.issn1555-9475en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1945en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34873
dc.identifier.volume12en_US
dc.identifier.wosWOS:000419750600033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNATURAL PRODUCTS INCen_US
dc.relation.ispartofNATURAL PRODUCT COMMUNICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPrangos gaubaeen_US
dc.subjectDiabetes mellitusen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectObesityen_US
dc.subjectAntioxidanten_US
dc.subjectEssential oilen_US
dc.titleChemical Composition of Essential Oil, Antioxidant, Antidiabetic, Anti-obesity, and Neuroprotective Properties of Prangos gaubaeen_US
dc.typeArticleen_US

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