Effects of selenium on electrophysiological changes associated with diabetic peripheral neuropathy

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dc.contributor.authorAyaz, Murat
dc.contributor.authorKaptan, Hulagu
dc.date.accessioned2020-03-26T18:14:25Z
dc.date.available2020-03-26T18:14:25Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOur previous study has demonstrated that sodium selenite prevents oxidative stress, suggesting that selenium can improve diabetic peripheral neuropathy. Results from this study demonstrated that diabetes mellitus resulted in significant increased time to peak, as well as rheobase and chronaxie values. In addition, maximum depolarization, area under compound action potential, kinetics, and conduction velocities of fast and slow nerve fiber groups were decreased. Sodium selenite exhibited positive effects on alterations of diabetes mellitus-induced conduction velocity distribution. This neuroprotective effect was primarily observed in the area under compound action potential and compound action potential kinetic waveforms, as well as rheobase and chronaxie. Results from this study showed that selenium supplementation blocked the diabetes mellitus-induced shift of actively contributing nerve fibers, and restored levels towards age-matched control group values. Chronic selenate supplementation for experimental diabetic peripheral neuropathy exhibited protective effects in measured electrophysiological parameters.en_US
dc.description.sponsorshipScientific Committee Foundation of Selcuk University, Konya, TurkeySelcuk University [06401013]en_US
dc.description.sponsorshipSupported by: the Scientific Committee Foundation of Selcuk University (BAP Project No. 06401013), Konya, Turkey<SUP>star</SUP>en_US
dc.identifier.doi10.3969/j.issn.1673-5374.2011.08.006en_US
dc.identifier.endpage622en_US
dc.identifier.issn1673-5374en_US
dc.identifier.issn1876-7958en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://dx.doi.org/10.3969/j.issn.1673-5374.2011.08.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26418
dc.identifier.volume6en_US
dc.identifier.wosWOS:000290362500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSen_US
dc.relation.ispartofNEURAL REGENERATION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsciatic nerveen_US
dc.subjectdiabetic neuropathyen_US
dc.subjectstreptozotocinen_US
dc.subjectconduction velocity distributionen_US
dc.subjectsodium seleniteen_US
dc.titleEffects of selenium on electrophysiological changes associated with diabetic peripheral neuropathyen_US
dc.typeArticleen_US

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