Comparative pharmacokinetics of free and liposome-encapsulated ampicillin after intravenous and subcutaneous administrations

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dc.contributor.authorYapar, K
dc.contributor.authorBas, AL
dc.date.accessioned2020-03-26T16:48:01Z
dc.date.available2020-03-26T16:48:01Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPharmacokinetic properties of liposome-encapsulated (LEA) and free (FA) ampicillin after intravenous (IV) and subcutaneous (SC) administrations were compared in sheep. Six healthy adult sheep were used in this study. Ampicillin was encapsulated in multilamellar large vesicles (MLV). FA and LEA were administered at a single recommended dose (5 mg/kg) to the same individual sheep at 1-week interval. Concentrations of the drug in serum were determined by HPLC. Results indicated that, when LEA was administered IV and SC, mean residence time (MRT), elimination half-life (t(1/2beta)) and the volume of distribution (V-d) were higher (P<0.05), and clearance (Cl) was lower (P<0.05) than in the case of the free form. When the drug was administered SC, the area under the curve (AUC) and the time to peak concentration (t(max)) were significantly higher (P<0.05), and maximum concentration (C-max) of LEA was lower than those of the free form. The results obtained in the present study shown that liposome encapsulated ampicillin provided the effective and prolonged serum concentration after IV and SC administration.en_US
dc.identifier.endpage510en_US
dc.identifier.issn0042-4870en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage507en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18973
dc.identifier.volume48en_US
dc.identifier.wosWOS:000226103200030en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNATL VETERINARY RESEARCH INSTen_US
dc.relation.ispartofBULLETIN OF THE VETERINARY INSTITUTE IN PULAWYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsheepen_US
dc.subjectampicillinen_US
dc.subjectpharmacokineticsen_US
dc.subjectliposomeen_US
dc.subjectmultilamellar vesicleen_US
dc.titleComparative pharmacokinetics of free and liposome-encapsulated ampicillin after intravenous and subcutaneous administrationsen_US
dc.typeArticleen_US

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